E0781 HCPCS code: Ambulatory infusion pump, single or multiple channels, electric or battery operated, with administrative equipment, worn by patient

E0781 is the HCPCS Level II code for ambulatory infusion pump, single or multiple channels, electric or battery operated, with administrative equipment, worn by patient. The 2026 Medicare DMEPOS fee schedule pays $309.33 to $396.36 (RR, rental (monthly)) depending on the state. Its Medicare coverage code is D (Special coverage instructions apply): Medicare covers it when its national or local coverage criteria are met. The NCCI unit limit is 1 per day on DME suppliers. Medicare volume fell 8% from 2022 to 2024 (17,527 to 16,144 services). In 2024, 439 suppliers billed Medicare for E0781 (rentals), serving 4,847 beneficiaries; Pennsylvania, New Jersey, Texas accounted for 34% of services. Its average fee ranks 13 of 27 E07 codes billed RR (family range $6.81–$16,384.73); rural fees run 6% higher.

Code details

2026 Medicare DMEPOS fee schedule for E0781

How the E0781 fee compares

Who bills E0781 (2024)

Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.

Medicare utilization for E0781, 2022–2024

States with the most E0781 services (2024)

NCCI unit limits (MUE)

Medicare policy articles for this code

• A52507: External Infusion Pumps - Policy Article (CGS Administrators, LLC (DME MAC) Noridian Healthcare Solutions, LLC (DME MAC)) — mentions this code in its coding guidance

Covered diagnoses (460 ICD-10-CM codes)

The diagnoses most often listed as covered in the policy articles above:

Showing 10 of 460. The full list, non-covered diagnoses and CSV export are in Caduvo.

What changed for E0781

• 2026-01-01: Average state fee (RR) rose 2.6%: $306.17 to $314.22
• 1987-01-01: E0781 added to HCPCS Level II
• Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01

Frequently asked questions

What is HCPCS code E0781?

E0781 is the HCPCS Level II code for ambulatory infusion pump, single or multiple channels, electric or battery operated, with administrative equipment, worn by patient. Short descriptor: "External ambulatory infus pu".

How much does Medicare pay for E0781?

Under the 2026 DMEPOS fee schedule, non-rural state fees are RR (rental (monthly)): $309.33–$396.36. Rural fees can be higher.

Does Medicare cover E0781?

Coverage code D — Special coverage instructions apply. Medicare covers it when its national or local coverage criteria are met.

Which diagnoses support coverage for E0781?

Medicare policy articles that cite E0781 list 460 covered ICD-10-CM diagnosis codes across 1 article. The most cited include C91.00 (Acute lymphoblastic leukemia not having achieved remission), C91.01 (Acute lymphoblastic leukemia, in remission), C91.02 (Acute lymphoblastic leukemia, in relapse). A listed diagnosis is necessary but not sufficient; the policy's other criteria still apply.

Did the Medicare fee for E0781 change in 2026?

The average non-rural state fee for RR moved from $306.17 in 2025 to $314.22 in 2026 (+2.6%). CMS's next quarterly HCPCS and DMEPOS update takes effect January 1, 2027.

How many units of E0781 can be billed per day?

1 on DME suppliers; 1 on outpatient hospital claims; 1 on practitioner claims (NCCI medically unlikely edits).

Related E07 codes

• E0700 — Safety equipment, device or accessory, any type
• E0705 — Transfer device, any type, each ($5.34–$134.77)
• E0710 — Restraints, any type (body, chest, wrist or ankle)
• E0711 — Upper extremity medical tubing/lines enclosure or covering device, restricts elbow range of motion
• E0715 — Intravaginal device intended to strengthen pelvic floor muscles during kegel exercises
• E0716 — Supplies and accessories for intravaginal device intended to strengthen pelvic floor muscles during kegel exercises
• E0720 — Transcutaneous electrical nerve stimulation (TENS) device, two lead, localized stimulation ($66.89–$393.27)
• E0721 — Transcutaneous electrical nerve stimulator for nerves in the auricular region
• E0730 — Transcutaneous electrical nerve stimulation (TENS) device, four or more leads, for multiple nerve stimulation ($68.53–$425.83)
• E0731 — Form fitting conductive garment for delivery of tens or nmes (with conductive fibers separated from the patient's skin by layers of fabric) ($87.58–$480.99)
• E0732 — Cranial electrotherapy stimulation (ces) system, any type ($31.06–$69.51)
• E0733 — Transcutaneous electrical nerve stimulator for electrical stimulation of the trigeminal nerve ($31.06–$69.51)

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Next steps

• Run a reimbursement report for a device billed under E0781
• Watch E0781 for fee, coverage and descriptor changes
• Build a full Medicare revenue model for E0781

Sources: CMS HCPCS Level II release October 2026; CMS DMEPOS fee schedule 2026; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.

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