G2215 HCPCS code: Take-home supply of nasal naloxone; 2-pack of 4mg per 0.1 ml nasal spray (provision of the services by a medicare-enrolled opioid treatment program); list separately in addition to code for primary procedure

G2215 is the HCPCS Level II code for take-home supply of nasal naloxone; 2-pack of 4mg per 0.1 ml nasal spray (provision of the services by a medicare-enrolled opioid treatment program); list separately in addition to code for primary procedure. In 2024 Medicare paid an average of $53.96 per service for G2215 across 460 services. Its Medicare coverage code is C (Carrier judgment): Coverage is decided by the Medicare contractor (MAC) case by case. Medicare volume rose 112% from 2022 to 2024 (217 to 460 services). In 2024, about 41 clinicians billed Medicare for G2215 for 236 beneficiaries; Michigan, Washington, California accounted for 83% of services.

Code details

Who bills G2215 (2024)

Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.

Medicare utilization for G2215, 2022–2024

States with the most G2215 services (2024)

Medicare policy articles for this code

• A59718: Billing and Coding: Opioid Treatment Programs (Palmetto GBA (MAC - Part A, MAC - Part B))

Covered diagnoses (39 ICD-10-CM codes)

The diagnoses most often listed as covered in the policy articles above:

Showing 10 of 39. The full list, non-covered diagnoses and CSV export are in Caduvo.

What changed for G2215

• 2021-01-01: G2215 added to HCPCS Level II
• Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01

Frequently asked questions

What is HCPCS code G2215?

G2215 is the HCPCS Level II code for take-home supply of nasal naloxone; 2-pack of 4mg per 0.1 ml nasal spray (provision of the services by a medicare-enrolled opioid treatment program); list separately in addition to code for primary procedure. Short descriptor: "Home supply nasal naloxone".

How much does Medicare pay for G2215?

In 2024, the average Medicare payment was $53.96 per service (average allowed $54.47).

Does Medicare cover G2215?

Coverage code C — Carrier judgment. Coverage is decided by the Medicare contractor (MAC) case by case.

Which diagnoses support coverage for G2215?

Medicare policy articles that cite G2215 list 39 covered ICD-10-CM diagnosis codes across 1 article. The most cited include F11.10 (Opioid abuse, uncomplicated), F11.11 (Opioid abuse, in remission), F11.120 (Opioid abuse with intoxication, uncomplicated). A listed diagnosis is necessary but not sufficient; the policy's other criteria still apply.

Related G22 codes

• G2200 — Patient identified as an unhealthy alcohol user received brief counseling
• G2201 — Documentation of medical reason(s) for not providing brief counseling (e.g., limited life expectancy, other medical reasons)
• G2202 — Patient did not receive brief counseling if identified as an unhealthy alcohol user
• G2203 — Documentation of medical reason(s) for not providing brief counseling if identified as an unhealthy alcohol user (e.g., limited life expectancy, other medical reasons)
• G2204 — Patients between 45 and 85 years of age who received a screening colonoscopy during the performance period
• G2205 — Patients with pregnancy during adjuvant treatment course
• G2206 — Patient received adjuvant treatment course including both chemotherapy and her2-targeted therapy
• G2207 — Reason for not administering adjuvant treatment course including both chemotherapy and her2-targeted therapy (e.g. poor performance status (ecog 3-4; karnofsky <=50), cardiac contraindications, insufficient renal function, insufficient hepatic function, other active or secondary cancer diagnoses, other medical contraindications, patients who died during initial treatment course or transferred during or after initial treatment course)
• G2208 — Patient did not receive adjuvant treatment course including both chemotherapy and her2-targeted therapy
• G2209 — Patient refused to participate
• G2210 — Residual score for the neck impairment not measured because the patient did not complete the neck fs prom at initial evaluation and/or near discharge, reason not given
• G2211 — Visit complexity inherent to evaluation and management associated with medical care services that serve as the continuing focal point for all needed health care services and/or with medical care services that are part of ongoing care related to a patient's single, serious condition or a complex condition. (add-on code, list separately in addition to office/outpatient evaluation and management visit, new or established)

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Next steps

• Run a reimbursement report for a device billed under G2215
• Watch G2215 for fee, coverage and descriptor changes
• Build a full Medicare revenue model for G2215

Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.

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