J3385 HCPCS code: Injection, velaglucerase alfa, 100 units
J3385 is the HCPCS Level II code for injection, velaglucerase alfa, 100 units. In 2024 Medicare paid an average of $282.16 per service for J3385 across 34,872 services. Its Medicare coverage code is C (Carrier judgment): Coverage is decided by the Medicare contractor (MAC) case by case. The NCCI unit limit is 80 per day on outpatient hospital claims. Medicare volume rose 22% from 2022 to 2024 (28,513 to 34,872 services). In 2024, about 114 clinicians billed Medicare for J3385 for 43 beneficiaries.
Code details
| Field | Value |
|---|---|
| Section | J codes — Drugs administered other than oral method |
| Coverage code | C — Carrier judgment |
| Pricing indicator | 51 — Drug or biological (priced per ASP/average sales price rules) |
| BETOS category | O1E — Other drugs |
| Added | 2011-01-01 |
| Last action effective | 2011-01-01 |
Who bills J3385 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 114 |
| Medicare beneficiaries | 43 |
| States with claims | 0 |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for J3385, 2022–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 28,513 | 42 | $355.74 | $283.74 |
| 2023 | 34,285 | 44 | $351.95 | $280.33 |
| 2024 | 34,872 | 43 | $354.30 | $282.16 |
NCCI unit limits (MUE)
| Claim type | Max units per day | Rationale |
|---|---|---|
| outpatient hospital claims | 80 | Clinical: Data |
| practitioner claims | 80 | Clinical: Data |
What changed for J3385
- 2011-01-01: J3385 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code J3385?
J3385 is the HCPCS Level II code for injection, velaglucerase alfa, 100 units. Short descriptor: "Velaglucerase alfa".
How much does Medicare pay for J3385?
In 2024, the average Medicare payment was $282.16 per service (average allowed $354.30).
Does Medicare cover J3385?
Coverage code C — Carrier judgment. Coverage is decided by the Medicare contractor (MAC) case by case.
How many units of J3385 can be billed per day?
80 on outpatient hospital claims; 80 on practitioner claims (NCCI medically unlikely edits).
Related J33 codes
- J3300 — Injection, triamcinolone acetonide, preservative free, 1 mg
- J3301 — Injection, triamcinolone acetonide, not otherwise specified, 10 mg
- J3302 — Injection, triamcinolone diacetate, per 5 mg
- J3303 — Injection, triamcinolone hexacetonide, per 5 mg
- J3304 — Injection, triamcinolone acetonide, preservative-free, extended-release, microsphere formulation, 1 mg
- J3305 — Injection, trimetrexate glucuronate, per 25 mg
- J3310 — Injection, perphenazine, up to 5 mg
- J3315 — Injection, triptorelin pamoate, 3.75 mg
- J3316 — Injection, triptorelin, extended-release, 3.75 mg
- J3320 — Injection, spectinomycin dihydrochloride, up to 2 gm
- J3350 — Injection, urea, up to 40 gm
- J3355 — Injection, urofollitropin, 75 iu
Building a device that would bill under a code like this? Caduvo matches a device description to HCPCS/CPT codes, Medicare coverage and payment, and the FDA pathway in one report.
Next steps
- Run a reimbursement report for a device billed under J3385
- Watch J3385 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for J3385
Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.