E77.0: Defects in post-translational modification of lysosomal enzymes
E77.0, defects in post-translational modification of lysosomal enzymes, is listed as a covered diagnosis in 5 Medicare billing and coding articles that apply to 1 HCPCS Level II code, including G0127 (Trimming of dystrophic nails, any number). The articles come from 5 Medicare contractors. A listed diagnosis supports medical necessity only; coverage still depends on the LCD's criteria and on documentation in the medical record.
HCPCS Level II codes with E77.0 as a covered diagnosis
| Code | Description | Medicare coverage | DMEPOS fee 2026 (state range) | Articles listing it |
|---|---|---|---|---|
| G0127 | Trimming of dystrophic nails, any number | Special coverage instructions apply | — | 5 |
Medicare policy articles listing E77.0
- A57759: Billing and Coding: Routine Foot Care and Debridement of Nails (Wellpoint Federal (MAC - Part A, MAC - Part B); 1 Level II codes). LCD with the same title: L33636, L34246
- A57193: Billing and Coding: Routine Foot Care and Debridement of Nails (CGS Administrators, LLC (MAC - Part A, MAC - Part B); 1 Level II codes). LCD with the same title: L33636, L34246
- A52996: Billing and Coding: Routine Foot Care (Novitas Solutions, Inc. (MAC - Part A, MAC - Part B); 1 Level II codes). LCD with the same title: L33941, L35138, L37643
- A56232: Billing and Coding: Foot Care (WPS Insurance Corporation (MAC - Part A, MAC - Part B); 1 Level II codes)
- A57188: Billing and Coding: Routine Foot Care (First Coast Service Options, Inc. (MAC - Part B); 1 Level II codes). LCD with the same title: L33941, L35138, L37643
A diagnosis listed as covered in a billing and coding article supports medical necessity for the article's codes; it does not guarantee payment. Coverage depends on the LCD's criteria, the contractor's jurisdiction and documentation in the medical record.
Other E77 diagnoses (Disorders of glycoprotein metabolism)
- E77.1 — Defects in glycoprotein degradation
- E77.8 — Other disorders of glycoprotein metabolism
- E77.9 — Disorder of glycoprotein metabolism, unspecified
Frequently asked questions
Does Medicare cover E77.0 (Defects in post-translational modification of lysosomal…)?
Medicare covers items and services, not diagnoses. 5 Medicare billing and coding articles list E77.0 as a covered diagnosis for 1 HCPCS Level II code: the diagnosis can support medical necessity for those codes, but payment still depends on the LCD's coverage criteria and the medical record.
Which HCPCS codes can be billed with ICD-10 E77.0?
The Level II codes from the policies most specific to this diagnosis are G0127 (Trimming of dystrophic nails, any number, 5 articles). Code choice depends on the item supplied; check each code's descriptor.
Which Medicare policy articles list E77.0?
A57759 (Billing and Coding: Routine Foot Care and Debridement of Nails); A57193 (Billing and Coding: Routine Foot Care and Debridement of Nails); A52996 (Billing and Coding: Routine Foot Care), and 2 more articles.
What is ICD-10-CM code E77.0?
E77.0 is the ICD-10-CM code for defects in post-translational modification of lysosomal enzymes, in category E77 (Disorders of glycoprotein metabolism), chapter 4: Endocrine, nutritional and metabolic diseases.
Next steps
- Run a reimbursement report for a device billed under G0127
- Watch G0127 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for G0127
Sources: CMS Medicare Coverage Database billing and coding articles (covered ICD-10 code lists and HCPCS links); ICD-10-CM FY2026; CMS HCPCS Level II release October 2026; CMS DMEPOS fee schedule 2026 (non-rural state fees). Not billing or legal advice.
Chapter 4: Endocrine, nutritional and metabolic diseases · All diagnoses · HCPCS lookup