G35.C0: Secondary progressive multiple sclerosis, unspecified

G35.C0, secondary progressive multiple sclerosis, unspecified, is listed as a covered diagnosis in 26 Medicare billing and coding articles that apply to 102 HCPCS Level II codes, including J0585 (Injection, onabotulinumtoxina, 1 unit), J0588 (Injection, incobotulinumtoxin a, 1 unit), J0586 (Injection, abobotulinumtoxina, 5 units). 55 of these codes have a 2026 DMEPOS fee schedule amount; A7020 pays $19.87 to $23.81 (NU) depending on the state. The articles come from 5 Medicare contractors. A listed diagnosis supports medical necessity only; coverage still depends on the LCD's criteria and on documentation in the medical record.

HCPCS Level II codes with G35.C0 as a covered diagnosis

CodeDescriptionMedicare coverageDMEPOS fee 2026 (state range)Articles listing it
J0585Injection, onabotulinumtoxina, 1 unitSpecial coverage instructions apply—6
J0588Injection, incobotulinumtoxin a, 1 unitCarrier judgment—6
J0586Injection, abobotulinumtoxina, 5 unitsCarrier judgment—6
J0587Injection, rimabotulinumtoxinb, 100 unitsSpecial coverage instructions apply—6
J0589Injection, daxibotulinumtoxina-lanm, 1 unitCarrier judgment—6
J9312Injection, rituximab, 10 mgSpecial coverage instructions apply—3
Q5119Injection, rituximab-pvvr, biosimilar, (ruxience), 10 mgCarrier judgment—3
Q5115Injection, rituximab-abbs, biosimilar, (truxima), 10 mgSpecial coverage instructions apply—3
G0127Trimming of dystrophic nails, any numberSpecial coverage instructions apply—4
J1569Injection, immune globulin, (gammagard liquid/gammagard liquid erc), 500 mgSpecial coverage instructions apply—2
J1561Injection, immune globulin, (gamunex-c/gammaked), non-lyophilized (e.g., liquid), 500 mgSpecial coverage instructions apply—2
J1459Injection, immune globulin (privigen), intravenous, non-lyophilized (e.g., liquid), 500 mgCarrier judgment—2
J1557Injection, immune globulin, (gammaplex), intravenous, non-lyophilized (e.g., liquid), 500 mgCarrier judgment—2
J1556Injection, immune globulin (bivigam), 500 mgCarrier judgment—2
J1568Injection, immune globulin, (octagam), intravenous, non-lyophilized (e.g., liquid), 500 mgCarrier judgment—2
J1566Injection, immune globulin, intravenous, lyophilized (e.g., powder), not otherwise specified, 500 mgSpecial coverage instructions apply—2
A7020Interface for cough stimulating device, includes all components, replacement onlyCarrier judgment$19.87–$23.81 (NU)1
E0483High frequency chest wall oscillation system, with full anterior and/or posterior thoracic region receiving simultaneous external oscillation, includes all accessories and supplies, eachCarrier judgment$1,515.12–$1,818.13 (RR)1
A7025High frequency chest wall oscillation system vest, replacement for use with patient owned equipment, eachCarrier judgment$61.99–$74.42 (RR)1
A7026High frequency chest wall oscillation system hose, replacement for use with patient owned equipment, eachCarrier judgment$40.96–$49.15 (NU)1
J1572Injection, immune globulin, (flebogamma/flebogamma dif), intravenous, non-lyophilized (e.g., liquid), 500 mgSpecial coverage instructions apply—1
J1552Injection, immune globulin (alyglo), 500 mgCarrier judgment—1
Q5123Injection, rituximab-arrx, biosimilar, (riabni), 10 mgCarrier judgment—2
J1576Injection, immune globulin (panzyga), intravenous, non-lyophilized (e.g., liquid), 500 mgSpecial coverage instructions apply—1
J1554Injection, immune globulin (asceniv), 500 mgCarrier judgment—1

77 more codes are listed. See every code with payment by region in Caduvo.

Medicare policy articles listing G35.C0

11 more articles list G35.C0.

A diagnosis listed as covered in a billing and coding article supports medical necessity for the article's codes; it does not guarantee payment. Coverage depends on the LCD's criteria, the contractor's jurisdiction and documentation in the medical record.

Other G35 diagnoses (Multiple sclerosis)

Frequently asked questions

Does Medicare cover G35.C0 (Secondary progressive multiple sclerosis, unspecified)?

Medicare covers items and services, not diagnoses. 26 Medicare billing and coding articles list G35.C0 as a covered diagnosis for 102 HCPCS Level II codes: the diagnosis can support medical necessity for those codes, but payment still depends on the LCD's coverage criteria and the medical record.

Which HCPCS codes can be billed with ICD-10 G35.C0?

The Level II codes from the policies most specific to this diagnosis are J0585 (Injection, onabotulinumtoxina, 1 unit, 6 articles); J0588 (Injection, incobotulinumtoxin a, 1 unit, 6 articles); J0586 (Injection, abobotulinumtoxina, 5 units, 6 articles); J0587 (Injection, rimabotulinumtoxinb, 100 units, 6 articles); J0589 (Injection, daxibotulinumtoxina-lanm, 1 unit, 6 articles). Code choice depends on the item supplied; check each code's descriptor.

What does Medicare pay for equipment billed with G35.C0?

Under the 2026 DMEPOS fee schedule (non-rural state fees): A7020 $19.87 to $23.81 (NU); E0483 $1,515.12 to $1,818.13 (RR); A7025 $61.99 to $74.42 (RR); A7026 $40.96 to $49.15 (NU). Medicare pays 80% of the allowed amount after the Part B deductible.

Which Medicare policy articles list G35.C0?

A58582 (Billing and Coding: Off-label Use of Rituximab and Rituximab Biosimilars); A52510 (Mechanical In-exsufflation Devices - Policy Article); A52494 (High Frequency Chest Wall Oscillation Devices - Policy Article), and 23 more articles.

What is ICD-10-CM code G35.C0?

G35.C0 is the ICD-10-CM code for secondary progressive multiple sclerosis, unspecified, in category G35 (Multiple sclerosis), chapter 6: Diseases of the nervous system.

Next steps

Sources: CMS Medicare Coverage Database billing and coding articles (covered ICD-10 code lists and HCPCS links); ICD-10-CM FY2026; CMS HCPCS Level II release October 2026; CMS DMEPOS fee schedule 2026 (non-rural state fees). Not billing or legal advice.

Chapter 6: Diseases of the nervous system · All diagnoses · HCPCS lookup