A2021 HCPCS code: Neomatrix, per square centimeter (add-on, list separately in addition to primary procedure)
A2021 is the HCPCS Level II code for neomatrix, per square centimeter (add-on, list separately in addition to primary procedure). In 2024 Medicare paid an average of $1,041.98 per service for A2021 across 1,024 services. Its Medicare coverage code is C (Carrier judgment): Coverage is decided by the Medicare contractor (MAC) case by case. In 2024, about 20 clinicians billed Medicare for A2021 for 58 beneficiaries.
Code details
| Field | Value |
|---|---|
| Section | A codes — Transportation, medical/surgical supplies and miscellaneous |
| Coverage code | C — Carrier judgment |
| Pricing indicator | 11 — Priced using national relative value units (Physician Fee Schedule) |
| BETOS category | P5A |
| Added | 2023-04-01 |
| Last action effective | 2026-01-01 |
Who bills A2021 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 20 |
| Medicare beneficiaries | 58 |
| States with claims | 1 |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for A2021, 2024–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2024 | 1,024 | 58 | $1,306.73 | $1,041.98 |
States with the most A2021 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| Florida | 842 | $1,033.53 |
What changed for A2021
- January 2026: Descriptor revised (Was: Neomatrix, per square centimeter)
- 2023-04-01: A2021 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code A2021?
A2021 is the HCPCS Level II code for neomatrix, per square centimeter (add-on, list separately in addition to primary procedure). Short descriptor: "Neomatrix per sq cm".
How much does Medicare pay for A2021?
In 2024, the average Medicare payment was $1,041.98 per service (average allowed $1,306.73).
Does Medicare cover A2021?
Coverage code C — Carrier judgment. Coverage is decided by the Medicare contractor (MAC) case by case.
Related A20 codes
- A2001 — Innovamatrix ac, per square centimeter (add-on, list separately in addition to primary procedure)
- A2002 — Mirragen advanced wound matrix, per square centimeter (add-on, list separately in addition to primary procedure)
- A2004 — Xcellistem, 1 mg
- A2005 — Microlyte matrix, per square centimeter (add-on, list separately in addition to primary procedure)
- A2006 — Novosorb synpath dermal matrix, per square centimeter (add-on, list separately in addition to primary procedure)
- A2007 — Restrata, per square centimeter (add-on, list separately in addition to primary procedure)
- A2008 — Theragenesis, per square centimeter (add-on, list separately in addition to primary procedure)
- A2009 — Symphony, per square centimeter (add-on, list separately in addition to primary procedure)
- A2010 — Apis, per square centimeter (add-on, list separately in addition to primary procedure)
- A2011 — Supra sdrm, per square centimeter (add-on, list separately in addition to primary procedure)
- A2012 — Suprathel, per square centimeter (add-on, list separately in addition to primary procedure)
- A2013 — Innovamatrix fs, per square centimeter (add-on, list separately in addition to primary procedure)
Building a device that would bill under a code like this? Caduvo matches a device description to HCPCS/CPT codes, Medicare coverage and payment, and the FDA pathway in one report.
Next steps
- Run a reimbursement report for a device billed under A2021
- Watch A2021 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for A2021
Sources: CMS HCPCS Level II release October 2026; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.