A4100 HCPCS code: Skin substitute, fda cleared as a device, not otherwise specified
A4100 is the HCPCS Level II code for skin substitute, fda cleared as a device, not otherwise specified. Its Medicare coverage code is C (Carrier judgment): Coverage is decided by the Medicare contractor (MAC) case by case.
Code details
| Field | Value |
|---|---|
| Section | A codes — Transportation, medical/surgical supplies and miscellaneous |
| Coverage code | C — Carrier judgment |
| Pricing indicator | 13 |
| BETOS category | P5A |
| Added | 2022-04-01 |
| Last action effective | 2022-04-01 |
Medicare policy articles for this code
- A59764: Billing and Coding: Amniotic and Placental-Derived Product Injections and/or Applications for Musculoskeletal Indications, Non-Wound (First Coast Service Options, Inc. (MAC - Part A, MAC - Part B))
- A59766: Billing and Coding: Amniotic and Placental-Derived Product Injections and/or Applications for Musculoskeletal Indications, Non-Wound (Novitas Solutions, Inc. (MAC - Part A, MAC - Part B))
What changed for A4100
- 2022-04-01: A4100 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code A4100?
A4100 is the HCPCS Level II code for skin substitute, fda cleared as a device, not otherwise specified. Short descriptor: "Skin sub fda clrd as dev nos".
Does Medicare cover A4100?
Coverage code C — Carrier judgment. Coverage is decided by the Medicare contractor (MAC) case by case.
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Next steps
- Run a reimbursement report for a device billed under A4100
- Watch A4100 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for A4100
Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.