B4216 HCPCS code: Parenteral nutrition; additives (vitamins, trace elements, heparin, electrolytes), home mix, per day
B4216 is the HCPCS Level II code for parenteral nutrition; additives (vitamins, trace elements, heparin, electrolytes), home mix, per day. In 2024 Medicare paid an average of $8.54 per service for B4216 across 880 services. Its Medicare coverage code is D (Special coverage instructions apply): Medicare covers it when its national or local coverage criteria are met. The NCCI unit limit is 1 per day on DME suppliers. Medicare volume fell 38% from 2022 to 2024 (1,420 to 880 services). In 2024, 9 suppliers billed Medicare for B4216 (purchases), serving 12 beneficiaries.
Code details
| Field | Value |
|---|---|
| Section | B codes — Enteral and parenteral therapy |
| Coverage code | D — Special coverage instructions apply |
| Pricing indicator | 39 — DMEPOS: parenteral and enteral nutrition |
| BETOS category | O1C — Enteral and parenteral nutrition |
| Added | 1984-01-01 |
| Last action effective | 2002-01-01 |
Who bills B4216 (2024)
| Measure | Value |
|---|---|
| Suppliers billing rentals | — |
| Suppliers billing purchases | 9 |
| Referring clinicians | 17 |
| Medicare beneficiaries | 12 |
| States with claims | 2 |
| Year | Suppliers | Beneficiaries |
|---|---|---|
| 2022 | 10 | 26 |
| 2023 | 12 | 36 |
| 2024 | 9 | 12 |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for B4216, 2022–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 1,420 | 26 | $9.81 | $7.72 |
| 2023 | 2,657 | 36 | $10.30 | $8.07 |
| 2024 | 880 | 12 | $10.90 | $8.54 |
States with the most B4216 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| New Jersey | 449 | $8.58 |
| Alaska | 348 | $8.58 |
NCCI unit limits (MUE)
| Claim type | Max units per day | Rationale |
|---|---|---|
| DME suppliers | 1 | Code Descriptor / CPT Instruction |
Medicare policy articles for this code
- A58836: Parenteral Nutrition (CGS Administrators, LLC (DME MAC) Noridian Healthcare Solutions, LLC (DME MAC)) — mentions this code in its coding guidance
What changed for B4216
- 1984-01-01: B4216 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code B4216?
B4216 is the HCPCS Level II code for parenteral nutrition; additives (vitamins, trace elements, heparin, electrolytes), home mix, per day. Short descriptor: "Parenteral nutrition additiv".
How much does Medicare pay for B4216?
In 2024, the average Medicare payment was $8.54 per service (average allowed $10.90).
Does Medicare cover B4216?
Coverage code D — Special coverage instructions apply. Medicare covers it when its national or local coverage criteria are met.
How many units of B4216 can be billed per day?
1 on DME suppliers (NCCI medically unlikely edits).
Related B42 codes
- B4220 — Parenteral nutrition supply kit; premix, per day
- B4222 — Parenteral nutrition supply kit; home mix, per day
- B4224 — Parenteral nutrition administration kit, per day
Building a device that would bill under a code like this? Caduvo matches a device description to HCPCS/CPT codes, Medicare coverage and payment, and the FDA pathway in one report.
Next steps
- Run a reimbursement report for a device billed under B4216
- Watch B4216 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for B4216
Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.