C9250 HCPCS code: Human plasma fibrin sealant, vapor-heated, solvent-detergent (artiss), 2 ml
C9250 is the HCPCS Level II code for human plasma fibrin sealant, vapor-heated, solvent-detergent (artiss), 2 ml. In 2024 Medicare paid an average of $105.75 per service for C9250 across 512 services. Its Medicare coverage code is D (Special coverage instructions apply): Medicare covers it when its national or local coverage criteria are met. The NCCI unit limit is 5 per day on outpatient hospital claims. Medicare volume rose 37% from 2022 to 2024 (374 to 512 services). In 2024, about 33 clinicians billed Medicare for C9250 for 508 beneficiaries.
Code details
| Field | Value |
|---|---|
| Section | C codes — Outpatient PPS (hospital outpatient temporary codes) |
| Coverage code | D — Special coverage instructions apply |
| Pricing indicator | 53 |
| BETOS category | O1E — Other drugs |
| Added | 2009-07-01 |
| Last action effective | 2017-01-01 |
Who bills C9250 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 33 |
| Medicare beneficiaries | 508 |
| States with claims | 2 |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for C9250, 2022–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 374 | 369 | $182.77 | $145.82 |
| 2023 | 513 | 511 | $177.65 | $140.78 |
| 2024 | 512 | 508 | $132.69 | $105.75 |
States with the most C9250 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| North Carolina | 436 | $105.91 |
| New York | 19 | $107.54 |
NCCI unit limits (MUE)
| Claim type | Max units per day | Rationale |
|---|---|---|
| outpatient hospital claims | 5 | Clinical: Data |
| practitioner claims | 1 | Clinical: Data |
What changed for C9250
- 2009-07-01: C9250 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code C9250?
C9250 is the HCPCS Level II code for human plasma fibrin sealant, vapor-heated, solvent-detergent (artiss), 2 ml. Short descriptor: "Artiss fibrin sealant".
How much does Medicare pay for C9250?
In 2024, the average Medicare payment was $105.75 per service (average allowed $132.69).
Does Medicare cover C9250?
Coverage code D — Special coverage instructions apply. Medicare covers it when its national or local coverage criteria are met.
How many units of C9250 can be billed per day?
5 on outpatient hospital claims; 1 on practitioner claims (NCCI medically unlikely edits).
Related C92 codes
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- C9254 — Injection, lacosamide, 1 mg
- C9257 — Injection, bevacizumab, 0.25 mg
- C9275 — Injection, hexaminolevulinate hydrochloride, 100 mg, per study dose
- C9285 — Lidocaine 70 mg/tetracaine 70 mg, per patch
- C9290 — Injection, bupivacaine liposome, 1 mg
- C9293 — Injection, glucarpidase, 10 units
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Next steps
- Run a reimbursement report for a device billed under C9250
- Watch C9250 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for C9250
Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.