C9310 HCPCS code: Injection, leucovorin calcium (avyxa), 1 mg
C9310 is the HCPCS Level II code for injection, leucovorin calcium (avyxa), 1 mg. CMS terminated C9310 on 2026-09-30; do not bill it for later dates of service. Its Medicare coverage code is D (Special coverage instructions apply): Medicare covers it when its national or local coverage criteria are met.
Code details
| Field | Value |
|---|---|
| Section | C codes — Outpatient PPS (hospital outpatient temporary codes) |
| Coverage code | D — Special coverage instructions apply |
| Pricing indicator | 53 |
| BETOS category | O1E — Other drugs |
| Added | 2026-07-01 |
| Last action effective | 2026-10-01 |
| Terminated | 2026-09-30 |
What changed for C9310
- July 2026: Code appears in this HCPCS release
- 2026-10-01: Last CMS action: code discontinued
- 2026-07-01: C9310 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code C9310?
C9310 is the HCPCS Level II code for injection, leucovorin calcium (avyxa), 1 mg. Short descriptor: "Inj, leucovorin cal (avyxa)".
Does Medicare cover C9310?
Coverage code D — Special coverage instructions apply. Medicare covers it when its national or local coverage criteria are met.
Related C93 codes
- C9300 — Injection, indigotindisulfonate sodium, 1 mg
- C9301 — Obecabtagene autoleucel, up to 400 million cd19 car-positive viable t cells, including leukapheresis and dose preparation procedures, per therapeutic dose
- C9302 — Injection, zanidatamab-hrii, 2 mg
- C9303 — Injection, zolbetuximab-clzb, 1 mg
- C9304 — Injection, marstacimab-hncq, 0.5 mg
- C9305 — Injection, nipocalimab-aahu, 3 mg
- C9306 — Injection, telisotuzumab vedotin-tllv, 1 mg
- C9307 — Injection, linvoseltamab-gcpt, 1 mg
- C9308 — Injection, carboplatin (avyxa), 1 mg
- C9309 — Injection, onasemnogene abeparvovec-brve, per treatment
- C9311 — Injection, eplontersen, 1 mg (code may be used for medicare when drug administered under the direct supervision of a physician, not for use when drug is self administered)
- C9312 — Injection, trabectedin (apotex), not therapeutically equivalent to j9362, 0.01 mg
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Next steps
- Run a reimbursement report for a device billed under C9310
- Watch C9310 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for C9310
Sources: CMS HCPCS Level II release October 2026; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.