E0580 HCPCS code: Nebulizer, durable, glass or autoclavable plastic, bottle type, for use with regulator or flowmeter

E0580 is the HCPCS Level II code for nebulizer, durable, glass or autoclavable plastic, bottle type, for use with regulator or flowmeter. The 2026 Medicare DMEPOS fee schedule pays $164.65 to $182.27 (NU, new equipment, purchased) depending on the state. Its Medicare coverage code is D (Special coverage instructions apply): Medicare covers it when its national or local coverage criteria are met. The NCCI unit limit is 1 per day on DME suppliers. Its average fee ranks 2 of 4 E05 codes billed NU (family range $92.47–$198.77).

Code details

2026 Medicare DMEPOS fee schedule for E0580

How the E0580 fee compares

NCCI unit limits (MUE)

Medicare policy articles for this code

• A52466: Nebulizers - Policy Article (CGS Administrators, LLC (DME MAC) Noridian Healthcare Solutions, LLC (DME MAC)) — mentions this code in its coding guidance
• A52514: Oxygen and Oxygen Equipment - Policy Article (CGS Administrators, LLC (DME MAC) Noridian Healthcare Solutions, LLC (DME MAC)) — mentions this code in its coding guidance

Covered diagnoses (215 ICD-10-CM codes)

The diagnoses most often listed as covered in the policy articles above:

Showing 10 of 215. The full list, non-covered diagnoses and CSV export are in Caduvo.

What changed for E0580

• 2026-01-01: Average state fee (NU) rose 2.0%: $161.76 to $164.98
• 2026-01-01: Average state fee (RR) rose 2.0%: $16.18 to $16.50
• 2026-01-01: Average state fee (UE) rose 2.0%: $121.28 to $123.72
• 1986-01-01: E0580 added to HCPCS Level II
• Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01

Frequently asked questions

What is HCPCS code E0580?

E0580 is the HCPCS Level II code for nebulizer, durable, glass or autoclavable plastic, bottle type, for use with regulator or flowmeter. Short descriptor: "Nebulizer for use w/ regulat".

How much does Medicare pay for E0580?

Under the 2026 DMEPOS fee schedule, non-rural state fees are NU (new equipment, purchased): $164.65–$182.27; RR (rental (monthly)): $16.47–$18.24; UE (used equipment, purchased): $123.47–$136.70. Rural fees can be higher.

Does Medicare cover E0580?

Coverage code D — Special coverage instructions apply. Medicare covers it when its national or local coverage criteria are met.

Which diagnoses support coverage for E0580?

Medicare policy articles that cite E0580 list 215 covered ICD-10-CM diagnosis codes across 2 articles. The most cited include A15.0 (Tuberculosis of lung), A22.1 (Pulmonary anthrax), A37.01 (Whooping cough due to Bordetella pertussis with pneumonia). A listed diagnosis is necessary but not sufficient; the policy's other criteria still apply.

Did the Medicare fee for E0580 change in 2026?

The average non-rural state fee for NU moved from $161.76 in 2025 to $164.98 in 2026 (+2.0%). CMS's next quarterly HCPCS and DMEPOS update takes effect January 1, 2027.

How many units of E0580 can be billed per day?

1 on DME suppliers (NCCI medically unlikely edits).

Related E05 codes

• E0500 — Ippb machine, all types, with built-in nebulization; manual or automatic valves; internal or external power source ($132.97–$168.94)
• E0530 — Electronic positional obstructive sleep apnea treatment, with sensor, includes all components and accessories, any type ($37.12–$37.12)
• E0550 — Humidifier, durable for extensive supplemental humidification during ippb treatments or oxygen delivery ($60.73–$118.04)
• E0555 — Humidifier, durable, glass or autoclavable plastic bottle type, for use with regulator or flowmeter
• E0560 — Humidifier, durable for supplemental humidification during ippb treatment or oxygen delivery ($20.98–$225.28)
• E0561 — Humidifier, non-heated, used with positive airway pressure device ($8.46–$128.48)
• E0562 — Humidifier, heated, used with positive airway pressure device ($16.82–$316.53)
• E0565 — Compressor, air power source for equipment which is not self-contained or cylinder driven ($42.74–$82.96)
• E0570 — Nebulizer, with compressor ($6.09–$15.43)
• E0572 — Aerosol compressor, adjustable pressure, light duty for intermittent use ($29.16–$51.74)
• E0574 — Ultrasonic/electronic aerosol generator with small volume nebulizer ($48.76–$67.63)
• E0575 — Nebulizer, ultrasonic, large volume ($124.51–$159.48)

Building a device that would bill under a code like this? Caduvo matches a device description to HCPCS/CPT codes, Medicare coverage and payment, and the FDA pathway in one report.

Next steps

• Run a reimbursement report for a device billed under E0580
• Watch E0580 for fee, coverage and descriptor changes
• Build a full Medicare revenue model for E0580

Sources: CMS HCPCS Level II release October 2026; CMS DMEPOS fee schedule 2026; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.

All E codes · HCPCS lookup