G0452 HCPCS code: Molecular pathology procedure; physician interpretation and report
G0452 is the HCPCS Level II code for molecular pathology procedure; physician interpretation and report. In 2024 Medicare paid an average of $35.68 per service for G0452 across 163,339 services. Its Medicare coverage code is C (Carrier judgment): Coverage is decided by the Medicare contractor (MAC) case by case. The NCCI unit limit is 1 per day on outpatient hospital claims. Medicare volume fell 7% from 2022 to 2024 (174,721 to 163,339 services). In 2024, about 1,637 clinicians billed Medicare for G0452 for 94,580 beneficiaries; Texas, New York, California accounted for 35% of services.
Code details
| Field | Value |
|---|---|
| Section | G codes — Procedures and professional services (temporary) |
| Coverage code | C — Carrier judgment |
| Pricing indicator | 13 |
| BETOS category | T2D |
| Added | 2013-01-01 |
| Last action effective | 2013-01-01 |
Who bills G0452 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 1,637 |
| Medicare beneficiaries | 94,580 |
| States with claims | 40 |
| Share of services in top 3 states (Texas, New York, California) | 35% |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for G0452, 2022–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 174,721 | 90,861 | $46.73 | $35.90 |
| 2023 | 155,809 | 87,687 | $47.22 | $36.63 |
| 2024 | 163,339 | 94,580 | $46.01 | $35.68 |
States with the most G0452 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| Texas | 22,603 | $34.83 |
| New York | 19,121 | $38.92 |
| California | 15,102 | $38.94 |
| Arizona | 14,831 | $32.62 |
| Pennsylvania | 12,940 | $35.45 |
NCCI unit limits (MUE)
| Claim type | Max units per day | Rationale |
|---|---|---|
| outpatient hospital claims | 1 | Nature of Service/Procedure |
| practitioner claims | 6 | Clinical: Data |
Medicare policy articles for this code
- A58917: Billing and Coding: Molecular Pathology and Genetic Testing (Novitas Solutions, Inc. (MAC - Part A, MAC - Part B))
- A58918: Billing and Coding: Molecular Pathology and Genetic Testing (First Coast Service Options, Inc. (MAC - Part A, MAC - Part B))
Covered diagnoses (1 ICD-10-CM codes)
The diagnoses most often listed as covered in the policy articles above:
| ICD-10-CM | Diagnosis | Articles listing it |
|---|---|---|
| XX000 | Not Applicable | 1 |
What changed for G0452
- 2013-01-01: G0452 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code G0452?
G0452 is the HCPCS Level II code for molecular pathology procedure; physician interpretation and report. Short descriptor: "Molecular pathology interpr".
How much does Medicare pay for G0452?
In 2024, the average Medicare payment was $35.68 per service (average allowed $46.01).
Does Medicare cover G0452?
Coverage code C — Carrier judgment. Coverage is decided by the Medicare contractor (MAC) case by case.
Which diagnoses support coverage for G0452?
Medicare policy articles that cite G0452 list 1 covered ICD-10-CM diagnosis codes across 2 articles. The most cited include XX000 (Not Applicable). A listed diagnosis is necessary but not sufficient; the policy's other criteria still apply.
How many units of G0452 can be billed per day?
1 on outpatient hospital claims; 6 on practitioner claims (NCCI medically unlikely edits).
Related G04 codes
- G0400 — Home sleep test (hst) with type iv portable monitor, unattended; minimum of 3 channels
- G0402 — Initial preventive physical examination; face-to-face visit, services limited to new beneficiary during the first 12 months of medicare enrollment
- G0403 — Electrocardiogram, routine ecg with 12 leads; performed as a screening for the initial preventive physical examination with interpretation and report
- G0404 — Electrocardiogram, routine ecg with 12 leads; tracing only, without interpretation and report, performed as a screening for the initial preventive physical examination
- G0405 — Electrocardiogram, routine ecg with 12 leads; interpretation and report only, performed as a screening for the initial preventive physical examination
- G0406 — Follow-up inpatient consultation, limited, physicians typically spend 15 minutes communicating with the patient via telehealth
- G0407 — Follow-up inpatient consultation, intermediate, physicians typically spend 25 minutes communicating with the patient via telehealth
- G0408 — Follow-up inpatient consultation, complex, physicians typically spend 35 minutes communicating with the patient via telehealth
- G0409 — Social work and psychological services, directly relating to and/or furthering the patient's rehabilitation goals, each 15 minutes, face-to-face; individual (services provided by a corf-qualified social worker or psychologist in a corf)
- G0410 — Group psychotherapy other than of a multiple-family group, in a partial hospitalization or intensive outpatient setting, approximately 45 to 50 minutes
- G0411 — Interactive group psychotherapy, in a partial hospitalization or intensive outpatient setting, approximately 45 to 50 minutes
- G0412 — Open treatment of iliac spine(s), tuberosity avulsion, or iliac wing fracture(s), unilateral or bilateral for pelvic bone fracture patterns which do not disrupt the pelvic ring includes internal fixation, when performed
Building a device that would bill under a code like this? Caduvo matches a device description to HCPCS/CPT codes, Medicare coverage and payment, and the FDA pathway in one report.
Next steps
- Run a reimbursement report for a device billed under G0452
- Watch G0452 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for G0452
Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.