J0642 HCPCS code: Injection, levoleucovorin (khapzory), 0.5 mg
J0642 is the HCPCS Level II code for injection, levoleucovorin (khapzory), 0.5 mg. In 2024 Medicare paid an average of $1.23 per service for J0642 across 659,370 services. Its Medicare coverage code is C (Carrier judgment): Coverage is decided by the Medicare contractor (MAC) case by case. The NCCI unit limit is 1200 per day on outpatient hospital claims. Medicare volume fell 14% from 2022 to 2024 (769,257 to 659,370 services). In 2024, about 36 clinicians billed Medicare for J0642 for 111 beneficiaries.
Code details
| Field | Value |
|---|---|
| Section | J codes — Drugs administered other than oral method |
| Coverage code | C — Carrier judgment |
| Pricing indicator | 51 — Drug or biological (priced per ASP/average sales price rules) |
| BETOS category | O1E — Other drugs |
| Added | 2019-10-01 |
| Last action effective | 2024-01-01 |
Who bills J0642 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 36 |
| Medicare beneficiaries | 111 |
| States with claims | 1 |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for J0642, 2022–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 769,257 | 143 | $1.46 | $1.16 |
| 2023 | 834,647 | 144 | $1.33 | $1.06 |
| 2024 | 659,370 | 111 | $1.54 | $1.23 |
States with the most J0642 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| Alabama | 647,470 | $1.23 |
NCCI unit limits (MUE)
| Claim type | Max units per day | Rationale |
|---|---|---|
| outpatient hospital claims | 1200 | Prescribing Information |
| practitioner claims | 1200 | Prescribing Information |
What changed for J0642
- 2019-10-01: J0642 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code J0642?
J0642 is the HCPCS Level II code for injection, levoleucovorin (khapzory), 0.5 mg. Short descriptor: "Injection, khapzory, 0.5 mg".
How much does Medicare pay for J0642?
In 2024, the average Medicare payment was $1.23 per service (average allowed $1.54).
Does Medicare cover J0642?
Coverage code C — Carrier judgment. Coverage is decided by the Medicare contractor (MAC) case by case.
How many units of J0642 can be billed per day?
1200 on outpatient hospital claims; 1200 on practitioner claims (NCCI medically unlikely edits).
Related J06 codes
- J0600 — Injection, edetate calcium disodium, up to 1000 mg
- J0601 — Sevelamer carbonate (renvela or therapeutically equivalent), oral, 20 mg (for esrd on dialysis)
- J0602 — Sevelamer carbonate (renvela or therapeutically equivalent), oral, powder, 20 mg (for esrd on dialysis)
- J0603 — Sevelamer hydrochloride (renagel or therapeutically equivalent), oral, 20 mg (for esrd on dialysis)
- J0604 — Cinacalcet, oral, 1 mg, (for esrd on dialysis)
- J0605 — Sucroferric oxyhydroxide, oral, 5 mg (for esrd on dialysis)
- J0606 — Injection, etelcalcetide, 0.1 mg
- J0607 — Lanthanum carbonate, oral, 5 mg (for esrd on dialysis)
- J0608 — Lanthanum carbonate, oral, powder, 5 mg, not therapeutically equivalent to j0607 (for esrd on dialysis)
- J0609 — Ferric citrate, oral, 3 mg ferric iron, (for esrd on dialysis)
- J0610 — Injection, calcium gluconate (fresenius kabi), per 10 ml
- J0611 — Injection, calcium gluconate (wg critical care), per 10 ml
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Next steps
- Run a reimbursement report for a device billed under J0642
- Watch J0642 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for J0642
Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.