J1599 HCPCS code: Injection, immune globulin, intravenous, non-lyophilized (e.g., liquid), not otherwise specified, 500 mg
J1599 is the HCPCS Level II code for injection, immune globulin, intravenous, non-lyophilized (e.g., liquid), not otherwise specified, 500 mg. In 2023 Medicare paid an average of $83.79 per service for J1599 across 195,336 services. Its Medicare coverage code is C (Carrier judgment): Coverage is decided by the Medicare contractor (MAC) case by case. The NCCI unit limit is 300 per day on DME suppliers. Medicare volume rose 30% from 2022 to 2023 (150,109 to 195,336 services). In 2023, about 265 clinicians billed Medicare for J1599 for 606 beneficiaries; California, Tennessee, Alabama accounted for 61% of services.
Code details
| Field | Value |
|---|---|
| Section | J codes — Drugs administered other than oral method |
| Coverage code | C — Carrier judgment |
| Pricing indicator | 51 — Drug or biological (priced per ASP/average sales price rules) |
| BETOS category | O1E — Other drugs |
| Added | 2011-01-01 |
| Last action effective | 2011-01-01 |
Who bills J1599 (2023)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 265 |
| Medicare beneficiaries | 606 |
| States with claims | 13 |
| Share of services in top 3 states (California, Tennessee, Alabama) | 61% |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for J1599, 2022–2023
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 150,109 | 433 | $119.05 | $94.93 |
| 2023 | 195,336 | 606 | $105.23 | $83.79 |
States with the most J1599 services (2023)
| State | Services | Avg. paid |
|---|---|---|
| California | 44,553 | $55.08 |
| Tennessee | 40,511 | $54.71 |
| Alabama | 24,462 | $53.57 |
| Texas | 18,919 | $219.79 |
| Florida | 13,360 | $77.48 |
NCCI unit limits (MUE)
| Claim type | Max units per day | Rationale |
|---|---|---|
| DME suppliers | 300 | Clinical: Data |
| outpatient hospital claims | 300 | Clinical: Data |
| practitioner claims | 300 | Clinical: Data |
Medicare policy articles for this code
- A56718: Billing and Coding: Intravenous Immunoglobulin (IVIG) (Palmetto GBA (MAC - Part A, MAC - Part B))
- A57160: Billing and Coding: Immune Thrombocytopenia (ITP) Therapy (CGS Administrators, LLC (MAC - Part A, MAC - Part B))
- A57187: Billing and Coding: Immune Globulin Intravenous (IVIg) (Noridian Healthcare Solutions, LLC (MAC - Part A, MAC - Part B))
- A57554: Billing and Coding: Immune Globulins (WPS Insurance Corporation (MAC - Part A, MAC - Part B))
- A59105: Billing and Coding: Off-Label Use of Intravenous Immune Globulin (IVIG) (National Government Services, Inc. (MAC - Part A, MAC - Part B))
Covered diagnoses (1,433 ICD-10-CM codes)
The diagnoses most often listed as covered in the policy articles above:
| ICD-10-CM | Diagnosis | Articles listing it |
|---|---|---|
| D69.3 | Immune thrombocytopenic purpura | 5 |
| B20 | Human immunodeficiency virus [HIV] disease | 4 |
| C90.00 | Multiple myeloma not having achieved remission | 4 |
| C90.02 | Multiple myeloma in relapse | 4 |
| C91.10 | Chronic lymphocytic leukemia of B-cell type not having achieved remission | 4 |
| C91.12 | Chronic lymphocytic leukemia of B-cell type in relapse | 4 |
| D59.0 | Drug-induced autoimmune hemolytic anemia | 4 |
| D59.11 | Warm autoimmune hemolytic anemia | 4 |
| D59.12 | Cold autoimmune hemolytic anemia | 4 |
| D59.13 | Mixed type autoimmune hemolytic anemia | 4 |
Showing 10 of 1,433. The full list, non-covered diagnoses and CSV export are in Caduvo.
What changed for J1599
- 2011-01-01: J1599 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code J1599?
J1599 is the HCPCS Level II code for injection, immune globulin, intravenous, non-lyophilized (e.g., liquid), not otherwise specified, 500 mg. Short descriptor: "Ivig non-lyophilized, nos".
How much does Medicare pay for J1599?
In 2023, the average Medicare payment was $83.79 per service (average allowed $105.23).
Does Medicare cover J1599?
Coverage code C — Carrier judgment. Coverage is decided by the Medicare contractor (MAC) case by case.
Which diagnoses support coverage for J1599?
Medicare policy articles that cite J1599 list 1,433 covered ICD-10-CM diagnosis codes across 5 articles. The most cited include D69.3 (Immune thrombocytopenic purpura), B20 (Human immunodeficiency virus [HIV] disease), C90.00 (Multiple myeloma not having achieved remission). A listed diagnosis is necessary but not sufficient; the policy's other criteria still apply.
How many units of J1599 can be billed per day?
300 on DME suppliers; 300 on outpatient hospital claims; 300 on practitioner claims (NCCI medically unlikely edits).
Related J15 codes
- J1551 — Injection, immune globulin (cutaquig), 100 mg
- J1552 — Injection, immune globulin (alyglo), 500 mg
- J1554 — Injection, immune globulin (asceniv), 500 mg
- J1555 — Injection, immune globulin (cuvitru), 100 mg
- J1556 — Injection, immune globulin (bivigam), 500 mg
- J1557 — Injection, immune globulin, (gammaplex), intravenous, non-lyophilized (e.g., liquid), 500 mg
- J1558 — Injection, immune globulin (xembify), 100 mg
- J1559 — Injection, immune globulin (hizentra), 100 mg
- J1560 — Injection, gamma globulin, intramuscular, over 10 cc
- J1561 — Injection, immune globulin, (gamunex-c/gammaked), non-lyophilized (e.g., liquid), 500 mg
- J1562 — Injection, immune globulin (vivaglobin), 100 mg
- J1566 — Injection, immune globulin, intravenous, lyophilized (e.g., powder), not otherwise specified, 500 mg
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Next steps
- Run a reimbursement report for a device billed under J1599
- Watch J1599 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for J1599
Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.