J2405 HCPCS code: Injection, ondansetron hydrochloride, per 1 mg
J2405 is the HCPCS Level II code for injection, ondansetron hydrochloride, per 1 mg. In 2024 Medicare paid an average of $0.07 per service for J2405 across 1,875,351 services. Its Medicare coverage code is D (Special coverage instructions apply): Medicare covers it when its national or local coverage criteria are met. The NCCI unit limit is 64 per day on outpatient hospital claims. Medicare volume fell 16% from 2022 to 2024 (2,237,703 to 1,875,351 services). In 2024, about 16,405 clinicians billed Medicare for J2405 for 53,777 beneficiaries; California, Florida, Texas accounted for 41% of services.
Code details
| Field | Value |
|---|---|
| Section | J codes — Drugs administered other than oral method |
| Coverage code | D — Special coverage instructions apply |
| Pricing indicator | 51 — Drug or biological (priced per ASP/average sales price rules) |
| BETOS category | O1E — Other drugs |
| Added | 1993-01-01 |
| Last action effective | 1997-01-01 |
Who bills J2405 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 16,405 |
| Medicare beneficiaries | 53,777 |
| States with claims | 55 |
| Share of services in top 3 states (California, Florida, Texas) | 41% |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for J2405, 2022–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 2,237,703 | 57,052 | $0.08 | $0.07 |
| 2023 | 2,095,094 | 56,918 | $0.09 | $0.07 |
| 2024 | 1,875,351 | 53,777 | $0.09 | $0.07 |
States with the most J2405 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| California | 377,020 | $0.07 |
| Florida | 265,881 | $0.07 |
| Texas | 118,920 | $0.07 |
| Illinois | 93,010 | $0.07 |
| New Jersey | 81,312 | $0.07 |
NCCI unit limits (MUE)
| Claim type | Max units per day | Rationale |
|---|---|---|
| outpatient hospital claims | 64 | Prescribing Information |
| practitioner claims | 64 | Prescribing Information |
What changed for J2405
- 1993-01-01: J2405 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code J2405?
J2405 is the HCPCS Level II code for injection, ondansetron hydrochloride, per 1 mg. Short descriptor: "Ondansetron hcl injection".
How much does Medicare pay for J2405?
In 2024, the average Medicare payment was $0.07 per service (average allowed $0.09).
Does Medicare cover J2405?
Coverage code D — Special coverage instructions apply. Medicare covers it when its national or local coverage criteria are met.
How many units of J2405 can be billed per day?
64 on outpatient hospital claims; 64 on practitioner claims (NCCI medically unlikely edits).
Related J24 codes
- J2400 — Injection, chloroprocaine hydrochloride, per 30 ml
- J2401 — Injection, chloroprocaine hydrochloride, per 1 mg
- J2402 — Injection, chloroprocaine hydrochloride (clorotekal), per 1 mg
- J2403 — Chloroprocaine hcl ophthalmic, 3% gel, 1 mg
- J2404 — Injection, nicardipine, 0.1 mg
- J2406 — Injection, oritavancin (kimyrsa), 10 mg
- J2407 — Injection, oritavancin (orbactiv), 10 mg
- J2410 — Injection, oxymorphone hcl, up to 1 mg
- J2425 — Injection, palifermin, 50 micrograms
- J2426 — Injection, paliperidone palmitate extended release (invega sustenna), 1 mg
- J2427 — Injection, paliperidone palmitate extended release (invega hafyera, or invega trinza), 1 mg
- J2428 — Injection, paliperidone palmitate extended release (erzofri), 1 mg
Building a device that would bill under a code like this? Caduvo matches a device description to HCPCS/CPT codes, Medicare coverage and payment, and the FDA pathway in one report.
Next steps
- Run a reimbursement report for a device billed under J2405
- Watch J2405 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for J2405
Sources: CMS HCPCS Level II release October 2026; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.