J8510 HCPCS code: Busulfan; oral, 2 mg
J8510 is the HCPCS Level II code for busulfan; oral, 2 mg. In 2024 Medicare paid an average of $157.24 per service for J8510 across 460 services. Its Medicare coverage code is D (Special coverage instructions apply): Medicare covers it when its national or local coverage criteria are met. The NCCI unit limit is 5 per day on outpatient hospital claims. Medicare volume fell 65% from 2022 to 2024 (1,298 to 460 services). In 2024, 1 suppliers billed Medicare for J8510 (purchases), serving 0 beneficiaries.
Code details
| Field | Value |
|---|---|
| Section | J codes — Drugs administered other than oral method |
| Coverage code | D — Special coverage instructions apply |
| Pricing indicator | 51 — Drug or biological (priced per ASP/average sales price rules) |
| BETOS category | O1D — Chemotherapy |
| Added | 2000-01-01 |
| Last action effective | 2025-01-01 |
Who bills J8510 (2024)
| Measure | Value |
|---|---|
| Suppliers billing rentals | — |
| Suppliers billing purchases | 1 |
| Referring clinicians | 4 |
| Medicare beneficiaries | 0 |
| States with claims | 1 |
| Year | Suppliers | Beneficiaries |
|---|---|---|
| 2022 | 14 | 17 |
| 2023 | 6 | 0 |
| 2024 | 1 | 0 |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for J8510, 2022–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 1,298 | 17 | $36.03 | $28.16 |
| 2023 | 985 | 0 | $126.55 | $102.77 |
| 2024 | 460 | 0 | $164.25 | $157.24 |
States with the most J8510 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| Maryland | 360 | $141.35 |
NCCI unit limits (MUE)
| Claim type | Max units per day | Rationale |
|---|---|---|
| outpatient hospital claims | 5 | Prescribing Information |
What changed for J8510
- 2000-01-01: J8510 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code J8510?
J8510 is the HCPCS Level II code for busulfan; oral, 2 mg. Short descriptor: "Oral busulfan".
How much does Medicare pay for J8510?
In 2024, the average Medicare payment was $157.24 per service (average allowed $164.25).
Does Medicare cover J8510?
Coverage code D — Special coverage instructions apply. Medicare covers it when its national or local coverage criteria are met.
How many units of J8510 can be billed per day?
5 on outpatient hospital claims (NCCI medically unlikely edits).
Related J85 codes
- J8501 — Aprepitant, oral, 5 mg
- J8502 — Injection, aprepitant (aponvie), 1 mg
- J8515 — Cabergoline, oral, 0.25 mg
- J8520 — Capecitabine, oral, 150 mg
- J8521 — Capecitabine, oral, 500 mg
- J8522 — Capecitabine, oral, 50 mg
- J8530 — Cyclophosphamide; oral, 25 mg
- J8540 — Dexamethasone, oral, 0.25 mg
- J8541 — Dexamethasone (hemady), oral, 0.25 mg
- J8560 — Etoposide; oral, 50 mg
- J8562 — Fludarabine phosphate, oral, 10 mg
- J8565 — Gefitinib, oral, 250 mg
Building a device that would bill under a code like this? Caduvo matches a device description to HCPCS/CPT codes, Medicare coverage and payment, and the FDA pathway in one report.
Next steps
- Run a reimbursement report for a device billed under J8510
- Watch J8510 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for J8510
Sources: CMS HCPCS Level II release October 2026; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.