J9351 HCPCS code: Injection, topotecan, 0.1 mg
J9351 is the HCPCS Level II code for injection, topotecan, 0.1 mg. In 2024 Medicare paid an average of $0.85 per service for J9351 across 180,333 services. Its Medicare coverage code is C (Carrier judgment): Coverage is decided by the Medicare contractor (MAC) case by case. The NCCI unit limit is 120 per day on outpatient hospital claims. Medicare volume fell 34% from 2022 to 2024 (274,846 to 180,333 services). In 2024, about 696 clinicians billed Medicare for J9351 for 359 beneficiaries; Florida, Texas, California accounted for 55% of services.
Code details
| Field | Value |
|---|---|
| Section | J codes — Drugs administered other than oral method |
| Coverage code | C — Carrier judgment |
| Pricing indicator | 51 — Drug or biological (priced per ASP/average sales price rules) |
| BETOS category | O1D — Chemotherapy |
| Added | 2011-01-01 |
| Last action effective | 2018-01-01 |
Who bills J9351 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 696 |
| Medicare beneficiaries | 359 |
| States with claims | 9 |
| Share of services in top 3 states (Florida, Texas, California) | 55% |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for J9351, 2022–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 274,846 | 560 | $0.98 | $0.77 |
| 2023 | 243,254 | 467 | $0.89 | $0.70 |
| 2024 | 180,333 | 359 | $1.07 | $0.85 |
States with the most J9351 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| Florida | 29,224 | $0.82 |
| Texas | 22,974 | $0.85 |
| California | 16,764 | $0.86 |
| Minnesota | 12,372 | $0.85 |
| Illinois | 10,829 | $0.90 |
NCCI unit limits (MUE)
| Claim type | Max units per day | Rationale |
|---|---|---|
| outpatient hospital claims | 120 | Clinical: Society Comment |
| practitioner claims | 120 | Clinical: Society Comment |
What changed for J9351
- 2011-01-01: J9351 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code J9351?
J9351 is the HCPCS Level II code for injection, topotecan, 0.1 mg. Short descriptor: "Topotecan injection".
How much does Medicare pay for J9351?
In 2024, the average Medicare payment was $0.85 per service (average allowed $1.07).
Does Medicare cover J9351?
Coverage code C — Carrier judgment. Coverage is decided by the Medicare contractor (MAC) case by case.
How many units of J9351 can be billed per day?
120 on outpatient hospital claims; 120 on practitioner claims (NCCI medically unlikely edits).
Related J93 codes
- J9300 — Injection, gemtuzumab ozogamicin, 5 mg
- J9301 — Injection, obinutuzumab, 10 mg
- J9302 — Injection, ofatumumab, 10 mg
- J9303 — Injection, panitumumab, 10 mg
- J9304 — Injection, pemetrexed (pemfexy), 10 mg
- J9305 — Injection, pemetrexed, not otherwise specified, 10 mg
- J9306 — Injection, pertuzumab, 1 mg
- J9307 — Injection, pralatrexate, 1 mg
- J9308 — Injection, ramucirumab, 5 mg
- J9309 — Injection, polatuzumab vedotin-piiq, 1 mg
- J9310 — Injection, rituximab, 100 mg
- J9311 — Injection, rituximab 10 mg and hyaluronidase
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Next steps
- Run a reimbursement report for a device billed under J9351
- Watch J9351 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for J9351
Sources: CMS HCPCS Level II release October 2026; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.