Q4201 HCPCS code: Matrion, per square centimeter (add-on, list separately in addition to primary procedure)
Q4201 is the HCPCS Level II code for matrion, per square centimeter (add-on, list separately in addition to primary procedure). In 2024 Medicare paid an average of $82.23 per service for Q4201 across 976 services. Its Medicare coverage code is C (Carrier judgment): Coverage is decided by the Medicare contractor (MAC) case by case. Medicare volume fell 70% from 2022 to 2024 (3,287 to 976 services). In 2024, about 9 clinicians billed Medicare for Q4201 for 34 beneficiaries.
Code details
| Field | Value |
|---|---|
| Section | Q codes — Temporary codes |
| Coverage code | C — Carrier judgment |
| Pricing indicator | 11 — Priced using national relative value units (Physician Fee Schedule) |
| BETOS category | O1E — Other drugs |
| Added | 2019-01-01 |
| Last action effective | 2026-01-01 |
Who bills Q4201 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 9 |
| Medicare beneficiaries | 34 |
| States with claims | 1 |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for Q4201, 2022–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 3,287 | 75 | $281.52 | $224.46 |
| 2023 | 932 | 43 | $145.14 | $115.46 |
| 2024 | 976 | 34 | $103.30 | $82.23 |
States with the most Q4201 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| Illinois | 232 | $76.14 |
What changed for Q4201
- January 2026: Descriptor revised (Was: Matrion, per square centimeter)
- 2019-01-01: Q4201 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code Q4201?
Q4201 is the HCPCS Level II code for matrion, per square centimeter (add-on, list separately in addition to primary procedure). Short descriptor: "Matrion 1 sq cm".
How much does Medicare pay for Q4201?
In 2024, the average Medicare payment was $82.23 per service (average allowed $103.30).
Does Medicare cover Q4201?
Coverage code C — Carrier judgment. Coverage is decided by the Medicare contractor (MAC) case by case.
Related Q42 codes
- Q4200 — Skin te, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4202 — Keroxx (2.5g/cc), 1cc
- Q4203 — Derma-gide, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4204 — Xwrap, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4205 — Membrane graft or membrane wrap, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4206 — Fluid flow or fluid gf, 1 cc
- Q4207 — Carbon life, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4208 — Novafix, per square cenitmeter (add-on, list separately in addition to primary procedure)
- Q4209 — Surgraft, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4210 — Axolotl graft or axolotl dualgraft, per square centimeter
- Q4211 — Amnion bio or axobiomembrane, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4212 — Allogen, per cc
Building a device that would bill under a code like this? Caduvo matches a device description to HCPCS/CPT codes, Medicare coverage and payment, and the FDA pathway in one report.
Next steps
- Run a reimbursement report for a device billed under Q4201
- Watch Q4201 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for Q4201
Sources: CMS HCPCS Level II release October 2026; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.