Q4227 HCPCS code: Amniocore, per square centimeter
Q4227 is the HCPCS Level II code for amniocore, per square centimeter. In 2024 Medicare paid an average of $318.76 per service for Q4227 across 13,747 services. Its Medicare coverage code is C (Carrier judgment): Coverage is decided by the Medicare contractor (MAC) case by case. Medicare volume fell 65% from 2022 to 2024 (39,374 to 13,747 services). In 2024, about 107 clinicians billed Medicare for Q4227 for 137 beneficiaries; Indiana, California, Florida accounted for 70% of services.
Code details
| Field | Value |
|---|---|
| Section | Q codes — Temporary codes |
| Coverage code | C — Carrier judgment |
| Pricing indicator | 51 — Drug or biological (priced per ASP/average sales price rules) |
| BETOS category | O1E — Other drugs |
| Added | 2020-07-01 |
| Last action effective | 2020-07-01 |
Who bills Q4227 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 107 |
| Medicare beneficiaries | 137 |
| States with claims | 5 |
| Share of services in top 3 states (Indiana, California, Florida) | 70% |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for Q4227, 2022–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 39,374 | 362 | $456.30 | $363.92 |
| 2023 | 100,354 | 642 | $250.51 | $199.56 |
| 2024 | 13,747 | 137 | $400.16 | $318.76 |
States with the most Q4227 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| Indiana | 2,665 | $123.53 |
| California | 1,898 | $814.42 |
| Florida | 1,875 | $281.72 |
| Pennsylvania | 1,514 | $328.53 |
| New Jersey | 1,211 | $177.03 |
What changed for Q4227
- 2020-07-01: Q4227 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code Q4227?
Q4227 is the HCPCS Level II code for amniocore, per square centimeter. Short descriptor: "Amniocore per sq cm".
How much does Medicare pay for Q4227?
In 2024, the average Medicare payment was $318.76 per service (average allowed $400.16).
Does Medicare cover Q4227?
Coverage code C — Carrier judgment. Coverage is decided by the Medicare contractor (MAC) case by case.
Related Q42 codes
- Q4200 — Skin te, per square centimeter
- Q4201 — Matrion, per square centimeter
- Q4202 — Keroxx (2.5g/cc), 1cc
- Q4203 — Derma-gide, per square centimeter
- Q4204 — Xwrap, per square centimeter
- Q4205 — Membrane graft or membrane wrap, per square centimeter
- Q4206 — Fluid flow or fluid gf, 1 cc
- Q4208 — Novafix, per square cenitmeter
- Q4209 — Surgraft, per square centimeter
- Q4210 — Axolotl graft or axolotl dualgraft, per square centimeter
- Q4211 — Amnion bio or axobiomembrane, per square centimeter
- Q4212 — Allogen, per cc
Building a device that would bill under a code like this? Caduvo matches a device description to HCPCS/CPT codes, Medicare coverage and payment, and the FDA pathway in one report.
Next steps
- Run a reimbursement report for a device billed under Q4227
- Watch Q4227 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for Q4227
Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.