Q4301 HCPCS code: Activate matrix, per square centimeter
Q4301 is the HCPCS Level II code for activate matrix, per square centimeter. In 2024 Medicare paid an average of $1,915.31 per service for Q4301 across 24,823 services. Its Medicare coverage code is C (Carrier judgment): Coverage is decided by the Medicare contractor (MAC) case by case. In 2024, about 32 clinicians billed Medicare for Q4301 for 79 beneficiaries.
Code details
| Field | Value |
|---|---|
| Section | Q codes — Temporary codes |
| Coverage code | C — Carrier judgment |
| Pricing indicator | 51 — Drug or biological (priced per ASP/average sales price rules) |
| BETOS category | O1E — Other drugs |
| Added | 2024-01-01 |
| Last action effective | 2024-01-01 |
Who bills Q4301 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 32 |
| Medicare beneficiaries | 79 |
| States with claims | 3 |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for Q4301, 2024–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2024 | 24,823 | 79 | $2,403.91 | $1,915.31 |
States with the most Q4301 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| Oklahoma | 10,895 | $1,939.74 |
| Texas | 1,960 | $2,043.87 |
| Florida | 1,568 | $1,885.27 |
What changed for Q4301
- 2024-01-01: Q4301 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code Q4301?
Q4301 is the HCPCS Level II code for activate matrix, per square centimeter. Short descriptor: "Activate matrix, per sq cm".
How much does Medicare pay for Q4301?
In 2024, the average Medicare payment was $1,915.31 per service (average allowed $2,403.91).
Does Medicare cover Q4301?
Coverage code C — Carrier judgment. Coverage is decided by the Medicare contractor (MAC) case by case.
Related Q43 codes
- Q4300 — Acesso tl, per square centimeter
- Q4302 — Complete aca, per square centimeter
- Q4303 — Complete aa, per square centimeter
- Q4304 — Grafix plus, per square centimeter
- Q4305 — American amnion ac tri-layer, per square centimeter
- Q4306 — American amnion ac, per square centimeter
- Q4307 — American amnion, per square centimeter
- Q4308 — Sanopellis, per square centimeter
- Q4309 — Via matrix, per square centimeter
- Q4310 — Procenta, per 100 mg
- Q4311 — Acesso, per square centimeter
- Q4312 — Acesso ac, per square centimeter
Building a device that would bill under a code like this? Caduvo matches a device description to HCPCS/CPT codes, Medicare coverage and payment, and the FDA pathway in one report.
Next steps
- Run a reimbursement report for a device billed under Q4301
- Watch Q4301 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for Q4301
Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.