Q5105 HCPCS code: Injection, epoetin alfa-epbx, biosimilar, (retacrit) (for esrd on dialysis), 100 units
Q5105 is the HCPCS Level II code for injection, epoetin alfa-epbx, biosimilar, (retacrit) (for esrd on dialysis), 100 units. In 2024 Medicare paid an average of $0.55 per service for Q5105 across 9,196 services. Its Medicare coverage code is D (Special coverage instructions apply): Medicare covers it when its national or local coverage criteria are met. The NCCI unit limit is 400 per day on outpatient hospital claims. Medicare volume fell 2% from 2022 to 2024 (9,426 to 9,196 services). In 2024, about 30 clinicians billed Medicare for Q5105 for 39 beneficiaries.
Code details
| Field | Value |
|---|---|
| Section | Q codes — Temporary codes |
| Coverage code | D — Special coverage instructions apply |
| Pricing indicator | 57 |
| BETOS category | O1E — Other drugs |
| Added | 2018-07-01 |
| Last action effective | 2020-01-01 |
Who bills Q5105 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 30 |
| Medicare beneficiaries | 39 |
| States with claims | 1 |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for Q5105, 2022–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 9,426 | 59 | $0.81 | $0.62 |
| 2023 | 13,712 | 66 | $0.79 | $0.62 |
| 2024 | 9,196 | 39 | $0.72 | $0.55 |
States with the most Q5105 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| California | 7,631 | $0.55 |
NCCI unit limits (MUE)
| Claim type | Max units per day | Rationale |
|---|---|---|
| outpatient hospital claims | 400 | Clinical: Data |
| practitioner claims | 100 | Clinical: Data |
Medicare policy articles for this code
- A56462: Billing and Coding: Erythropoiesis Stimulating Agents (ESA) (CGS Administrators, LLC (MAC - Part A, MAC - Part B))
- A56795: Billing and Coding: Erythropoiesis Stimulating Agents (ESAs) (WPS Insurance Corporation (MAC - Part A, MAC - Part B))
- A58982: Billing and Coding: Erythropoiesis Stimulating Agents (Palmetto GBA (MAC - Part A, MAC - Part B))
- A58982: Billing and Coding: Erythropoiesis Stimulating Agents (Palmetto GBA (MAC - Part A, MAC - Part B))
- A60381: Billing and Coding: Erythropoiesis Stimulating Agents (Wellpoint Federal (MAC - Part A, MAC - Part B))
Covered diagnoses (1,489 ICD-10-CM codes)
The diagnoses most often listed as covered in the policy articles above:
| ICD-10-CM | Diagnosis | Articles listing it |
|---|---|---|
| B20 | Human immunodeficiency virus [HIV] disease | 4 |
| B97.35 | Human immunodeficiency virus, type 2 [HIV 2] as the cause of diseases classified elsewhere | 4 |
| D46.0 | Refractory anemia without ring sideroblasts, so stated | 4 |
| D46.1 | Refractory anemia with ring sideroblasts | 4 |
| D46.20 | Refractory anemia with excess of blasts, unspecified | 4 |
| D46.21 | Refractory anemia with excess of blasts 1 | 4 |
| D46.A | Refractory cytopenia with multilineage dysplasia | 4 |
| D46.B | Refractory cytopenia with multilineage dysplasia and ring sideroblasts | 4 |
| D46.C | Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality | 4 |
| D47.1 | Chronic myeloproliferative disease | 4 |
Showing 10 of 1,489. The full list, non-covered diagnoses and CSV export are in Caduvo.
What changed for Q5105
- 2018-07-01: Q5105 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code Q5105?
Q5105 is the HCPCS Level II code for injection, epoetin alfa-epbx, biosimilar, (retacrit) (for esrd on dialysis), 100 units. Short descriptor: "Inj retacrit esrd on dialysi".
How much does Medicare pay for Q5105?
In 2024, the average Medicare payment was $0.55 per service (average allowed $0.72).
Does Medicare cover Q5105?
Coverage code D — Special coverage instructions apply. Medicare covers it when its national or local coverage criteria are met.
Which diagnoses support coverage for Q5105?
Medicare policy articles that cite Q5105 list 1,489 covered ICD-10-CM diagnosis codes across 5 articles. The most cited include B20 (Human immunodeficiency virus [HIV] disease), B97.35 (Human immunodeficiency virus, type 2 [HIV 2] as the cause of diseases classified elsewhere), D46.0 (Refractory anemia without ring sideroblasts, so stated). A listed diagnosis is necessary but not sufficient; the policy's other criteria still apply.
How many units of Q5105 can be billed per day?
400 on outpatient hospital claims; 100 on practitioner claims (NCCI medically unlikely edits).
Related Q51 codes
- Q5100 — Injection, ustekinumab-kfce (yesintek), biosimilar, 1 mg
- Q5101 — Injection, filgrastim-sndz, biosimilar, (zarxio), 1 microgram
- Q5102 — Injection, infliximab, biosimilar, 10 mg
- Q5103 — Injection, infliximab-dyyb, biosimilar, (inflectra), 10 mg
- Q5104 — Injection, infliximab-abda, biosimilar, (renflexis), 10 mg
- Q5106 — Injection, epoetin alfa-epbx, biosimilar, (retacrit) (for non-esrd use), 1000 units
- Q5107 — Injection, bevacizumab-awwb, biosimilar, (mvasi), 10 mg
- Q5108 — Injection, pegfilgrastim-jmdb (fulphila), biosimilar, 0.5 mg
- Q5109 — Injection, infliximab-qbtx, biosimilar, (ixifi), 10 mg
- Q5110 — Injection, filgrastim-aafi, biosimilar, (nivestym), 1 microgram
- Q5111 — Injection, pegfilgrastim-cbqv (udenyca), biosimilar, 0.5 mg
- Q5112 — Injection, trastuzumab-dttb, biosimilar, (ontruzant), 10 mg
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Next steps
- Run a reimbursement report for a device billed under Q5105
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Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.