S0013 HCPCS code: Esketamine, nasal spray, 1 mg
S0013 is the HCPCS Level II code for esketamine, nasal spray, 1 mg. Its Medicare coverage code is I (Not payable by Medicare): Medicare does not pay separately under this code; another code applies.
Code details
| Field | Value |
|---|---|
| Section | S codes — Temporary national codes (non-Medicare) |
| Coverage code | I — Not payable by Medicare |
| Pricing indicator | 00 — Not separately priced by Medicare |
| BETOS category | Z2 |
| Added | 2021-01-01 |
| Last action effective | 2021-01-01 |
What changed for S0013
- 2021-01-01: S0013 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code S0013?
S0013 is the HCPCS Level II code for esketamine, nasal spray, 1 mg. Short descriptor: "Esketamine, nasal spray".
Does Medicare cover S0013?
Coverage code I — Not payable by Medicare. Medicare does not pay separately under this code; another code applies.
Related S00 codes
- S0012 — Butorphanol tartrate, nasal spray, 25 mg
- S0014 — Tacrine hydrochloride, 10 mg
- S0017 — Injection, aminocaproic acid, 5 grams
- S0020 — Injection, bupivicaine hydrochloride, 30 ml
- S0021 — Injection, cefoperazone sodium, 1 gram
- S0023 — Injection, cimetidine hydrochloride, 300 mg
- S0028 — Injection, famotidine, 20 mg
- S0030 — Injection, metronidazole, 500 mg
- S0032 — Injection, nafcillin sodium, 2 grams
- S0034 — Injection, ofloxacin, 400 mg
- S0039 — Injection, sulfamethoxazole and trimethoprim, 10 ml
- S0040 — Injection, ticarcillin disodium and clavulanate potassium, 3.1 grams
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Next steps
- Run a reimbursement report for a device billed under S0013
- Watch S0013 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for S0013
Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.