S3721 HCPCS code: Prostate cancer antigen 3 (pca3) testing
S3721 is the HCPCS Level II code for prostate cancer antigen 3 (pca3) testing. CMS terminated S3721 on 2015-12-31; do not bill it for later dates of service. Its Medicare coverage code is I (Not payable by Medicare): Medicare does not pay separately under this code; another code applies.
Code details
| Field | Value |
|---|---|
| Section | S codes — Temporary national codes (non-Medicare) |
| Coverage code | I — Not payable by Medicare |
| Pricing indicator | 00 — Not separately priced by Medicare |
| BETOS category | Z2 |
| Added | 2012-04-01 |
| Last action effective | 2016-01-01 |
| Terminated | 2015-12-31 |
What changed for S3721
- 2012-04-01: S3721 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code S3721?
S3721 is the HCPCS Level II code for prostate cancer antigen 3 (pca3) testing. Short descriptor: "Pca3 testing".
Does Medicare cover S3721?
Coverage code I — Not payable by Medicare. Medicare does not pay separately under this code; another code applies.
Related S37 codes
- S3708 — Gastrointestinal fat absorption study
- S3722 — Dose optimization by area under the curve (auc) analysis, for infusional 5-fluorouracil
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Next steps
- Run a reimbursement report for a device billed under S3721
- Watch S3721 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for S3721
Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.