S5521 HCPCS code: Home infusion therapy, all supplies (including catheter) necessary for a midline catheter insertion
S5521 is the HCPCS Level II code for home infusion therapy, all supplies (including catheter) necessary for a midline catheter insertion. Its Medicare coverage code is I (Not payable by Medicare): Medicare does not pay separately under this code; another code applies.
Code details
| Field | Value |
|---|---|
| Section | S codes — Temporary national codes (non-Medicare) |
| Coverage code | I — Not payable by Medicare |
| Pricing indicator | 00 — Not separately priced by Medicare |
| BETOS category | Z2 |
| Added | 2002-01-01 |
| Last action effective | 2002-01-01 |
What changed for S5521
- 2002-01-01: S5521 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code S5521?
S5521 is the HCPCS Level II code for home infusion therapy, all supplies (including catheter) necessary for a midline catheter insertion. Short descriptor: "Hit midline cath insert kit".
Does Medicare cover S5521?
Coverage code I — Not payable by Medicare. Medicare does not pay separately under this code; another code applies.
Related S55 codes
- S5501 — Home infusion therapy, catheter care / maintenance, complex (more than one lumen), includes administrative services, professional pharmacy services, care coordination, and all necessary supplies and equipment (drugs and nursing visits coded separately), per diem
- S5502 — Home infusion therapy, catheter care / maintenance, implanted access device, includes administrative services, professional pharmacy services, care coordination and all necessary supplies and equipment, (drugs and nursing visits coded separately), per diem (use this code for interim maintenance of vascular access not currently in use)
- S5517 — Home infusion therapy, all supplies necessary for restoration of catheter patency or declotting
- S5518 — Home infusion therapy, all supplies necessary for catheter repair
- S5520 — Home infusion therapy, all supplies (including catheter) necessary for a peripherally inserted central venous catheter (picc) line insertion
- S5522 — Home infusion therapy, insertion of peripherally inserted central venous catheter (picc), nursing services only (no supplies or catheter included)
- S5523 — Home infusion therapy, insertion of midline venous catheter, nursing services only (no supplies or catheter included)
- S5550 — Insulin, rapid onset, 5 units
- S5551 — Insulin, most rapid onset (lispro or aspart); 5 units
- S5552 — Insulin, intermediate acting (nph or lente); 5 units
- S5553 — Insulin, long acting; 5 units
- S5560 — Insulin delivery device, reusable pen; 1.5 ml size
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Next steps
- Run a reimbursement report for a device billed under S5521
- Watch S5521 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for S5521
Sources: CMS HCPCS Level II release October 2026; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.