E2100 HCPCS code: Blood glucose monitor with integrated voice synthesizer
E2100 is the HCPCS Level II code for blood glucose monitor with integrated voice synthesizer. The 2026 Medicare DMEPOS fee schedule pays $650.29 to $1,084.76 (NU, new equipment, purchased) depending on the state. Its Medicare coverage code is D (Special coverage instructions apply): Medicare covers it when its national or local coverage criteria are met. The NCCI unit limit is 1 per day on DME suppliers. Medicare volume fell 68% from 2022 to 2024 (1,152 to 363 services). In 2024, 56 suppliers billed Medicare for E2100 (purchases), serving 363 beneficiaries; New York, California, Florida accounted for 33% of services. Its average fee ranks 5 of 5 E21 codes billed NU (family range $54.52–$866.28).
Code details
| Field | Value |
|---|---|
| Section | E codes — Durable medical equipment |
| Coverage code | D — Special coverage instructions apply |
| Pricing indicator | 32 — DMEPOS: inexpensive or routinely purchased item |
| BETOS category | D1E — Other durable medical equipment |
| Added | 2002-01-01 |
| Last action effective | 2002-01-01 |
2026 Medicare DMEPOS fee schedule for E2100
| Modifier | Meaning | Lowest state fee | Highest state fee | Ceiling | Floor |
|---|---|---|---|---|---|
| NU | new equipment, purchased | $650.29 | $1,084.76 | $916.61 | $779.12 |
| RR | rental (monthly) | $76.49 | $135.63 | $91.69 | $77.94 |
| UE | used equipment, purchased | $440.60 | $813.58 | $687.49 | $584.37 |
| State | Modifier | Fee | Rural fee |
|---|---|---|---|
| AK | NU | $650.29 | — |
| AL | NU | $779.12 | — |
| AR | NU | $916.61 | — |
| AZ | NU | $916.61 | — |
| CA | NU | $779.12 | — |
| CO | NU | $860.22 | — |
| CT | NU | $916.61 | — |
| DC | NU | $903.96 | — |
| DE | NU | $779.12 | — |
| FL | NU | $779.12 | — |
| GA | NU | $779.12 | — |
| HI | NU | $695.40 | — |
| IA | NU | $916.61 | — |
| ID | NU | $779.12 | — |
| IL | NU | $916.61 | — |
| IN | NU | $779.12 | — |
| KS | NU | $916.61 | — |
| KY | NU | $916.61 | — |
| LA | NU | $916.61 | — |
| MA | NU | $916.61 | — |
| MD | NU | $916.61 | — |
| ME | NU | $916.61 | — |
| MI | NU | $779.12 | — |
| MN | NU | $886.84 | — |
| MO | NU | $916.61 | — |
| MS | NU | $916.61 | — |
| MT | NU | $896.77 | — |
| NC | NU | $903.96 | — |
| ND | NU | $916.61 | — |
| NE | NU | $916.61 | — |
| NH | NU | $916.61 | — |
| NJ | NU | $903.96 | — |
| NM | NU | $916.61 | — |
| NV | NU | $916.61 | — |
| NY | NU | $784.55 | — |
| OH | NU | $916.61 | — |
| OK | NU | $916.61 | — |
| OR | NU | $779.12 | — |
| PA | NU | $779.12 | — |
| PR | NU | $1,084.76 | — |
| RI | NU | $916.61 | — |
| SC | NU | $903.96 | — |
| SD | NU | $916.61 | — |
| TN | NU | $916.61 | — |
| TX | NU | $779.12 | — |
| UT | NU | $779.12 | — |
| VA | NU | $864.48 | — |
| VI | NU | $784.55 | — |
| VT | NU | $916.61 | — |
| WA | NU | $828.88 | — |
| WI | NU | $779.12 | — |
| WV | NU | $916.61 | — |
| WY | NU | $916.61 | — |
| AK | RR | $76.49 | — |
| AL | RR | $77.94 | — |
| AR | RR | $91.69 | — |
| AZ | RR | $91.69 | — |
| CA | RR | $77.94 | — |
| CO | RR | $77.94 | — |
| CT | RR | $91.69 | — |
| DC | RR | $77.94 | — |
| DE | RR | $77.94 | — |
| FL | RR | $77.94 | — |
| GA | RR | $77.94 | — |
| HI | RR | $81.76 | — |
| IA | RR | $91.69 | — |
| ID | RR | $77.94 | — |
| IL | RR | $91.69 | — |
| IN | RR | $77.94 | — |
| KS | RR | $91.69 | — |
| KY | RR | $91.69 | — |
| LA | RR | $91.69 | — |
| MA | RR | $91.69 | — |
| MD | RR | $88.20 | — |
| ME | RR | $91.69 | — |
| MI | RR | $77.94 | — |
| MN | RR | $88.66 | — |
| MO | RR | $91.69 | — |
| MS | RR | $91.69 | — |
| MT | RR | $89.66 | — |
| NC | RR | $90.41 | — |
| ND | RR | $91.69 | — |
| NE | RR | $91.69 | — |
| NH | RR | $91.69 | — |
| NJ | RR | $90.41 | — |
| NM | RR | $91.69 | — |
| NV | RR | $91.69 | — |
| NY | RR | $91.69 | — |
| OH | RR | $91.69 | — |
| OK | RR | $91.69 | — |
| OR | RR | $77.94 | — |
| PA | RR | $77.94 | — |
| PR | RR | $135.63 | — |
| RI | RR | $91.69 | — |
| SC | RR | $90.41 | — |
| SD | RR | $91.69 | — |
| TN | RR | $91.69 | — |
| TX | RR | $77.94 | — |
| UT | RR | $77.94 | — |
| VA | RR | $82.18 | — |
| VI | RR | $91.69 | — |
| VT | RR | $91.69 | — |
| WA | RR | $91.69 | — |
| WI | RR | $77.94 | — |
| WV | RR | $91.69 | — |
| WY | RR | $91.69 | — |
| AK | UE | $440.60 | — |
| AL | UE | $584.37 | — |
| AR | UE | $687.49 | — |
| AZ | UE | $687.49 | — |
| CA | UE | $584.37 | — |
| CO | UE | $584.37 | — |
| CT | UE | $687.49 | — |
| DC | UE | $678.02 | — |
| DE | UE | $584.37 | — |
| FL | UE | $584.37 | — |
| GA | UE | $584.37 | — |
| HI | UE | $471.15 | — |
| IA | UE | $687.49 | — |
| ID | UE | $584.37 | — |
| IL | UE | $687.49 | — |
| IN | UE | $584.37 | — |
| KS | UE | $687.49 | — |
| KY | UE | $687.49 | — |
| LA | UE | $687.49 | — |
| MA | UE | $687.49 | — |
| MD | UE | $687.49 | — |
| ME | UE | $687.49 | — |
| MI | UE | $584.37 | — |
| MN | UE | $665.09 | — |
| MO | UE | $687.49 | — |
| MS | UE | $687.49 | — |
| MT | UE | $672.57 | — |
| NC | UE | $678.02 | — |
| ND | UE | $687.49 | — |
| NE | UE | $687.49 | — |
| NH | UE | $687.49 | — |
| NJ | UE | $678.02 | — |
| NM | UE | $687.49 | — |
| NV | UE | $687.49 | — |
| NY | UE | $641.82 | — |
| OH | UE | $687.49 | — |
| OK | UE | $687.49 | — |
| OR | UE | $584.37 | — |
| PA | UE | $584.37 | — |
| PR | UE | $813.58 | — |
| RI | UE | $687.49 | — |
| SC | UE | $678.02 | — |
| SD | UE | $687.49 | — |
| TN | UE | $687.49 | — |
| TX | UE | $584.37 | — |
| UT | UE | $584.37 | — |
| VA | UE | $648.36 | — |
| VI | UE | $641.82 | — |
| VT | UE | $687.49 | — |
| WA | UE | $621.61 | — |
| WI | UE | $584.37 | — |
| WV | UE | $687.49 | — |
| WY | UE | $687.49 | — |
How the E2100 fee compares
| Measure | Value |
|---|---|
| Rank among 5 E21 codes billed NU (lowest = 1) | 5 |
| Family fee range (average of state fees) | $54.52–$866.28 |
| Rural fee uplift | — |
Who bills E2100 (2024)
| Measure | Value |
|---|---|
| Suppliers billing rentals | — |
| Suppliers billing purchases | 56 |
| Referring clinicians | 363 |
| Medicare beneficiaries | 363 |
| States with claims | 14 |
| Share of services in top 3 states (New York, California, Florida) | 33% |
| Year | Suppliers | Beneficiaries |
|---|---|---|
| 2022 | 104 | 1,152 |
| 2023 | 96 | 1,446 |
| 2024 | 56 | 363 |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for E2100, 2022–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 1,152 | 1,152 | $634.41 | $498.23 |
| 2023 | 1,447 | 1,446 | $709.93 | $550.81 |
| 2024 | 363 | 363 | $712.31 | $537.54 |
States with the most E2100 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| New York | 27 | $457.18 |
| California | 26 | $535.86 |
| Florida | 24 | $515.26 |
| Texas | 22 | $559.37 |
| Illinois | 20 | $623.92 |
NCCI unit limits (MUE)
| Claim type | Max units per day | Rationale |
|---|---|---|
| DME suppliers | 1 | Code Descriptor / CPT Instruction |
Medicare policy articles for this code
- A52464: Glucose Monitor - Policy Article (CGS Administrators, LLC (DME MAC) Noridian Healthcare Solutions, LLC (DME MAC)) — mentions this code in its coding guidance
Covered diagnoses (461 ICD-10-CM codes)
The diagnoses most often listed as covered in the policy articles above:
| ICD-10-CM | Diagnosis | Articles listing it |
|---|---|---|
| E08.00 | Diabetes mellitus due to underlying condition with hyperosmolarity without nonketotic hyperglycemic-hyperosmolar coma (NKHHC) | 1 |
| E08.01 | Diabetes mellitus due to underlying condition with hyperosmolarity with coma | 1 |
| E08.10 | Diabetes mellitus due to underlying condition with ketoacidosis without coma | 1 |
| E08.11 | Diabetes mellitus due to underlying condition with ketoacidosis with coma | 1 |
| E08.21 | Diabetes mellitus due to underlying condition with diabetic nephropathy | 1 |
| E08.22 | Diabetes mellitus due to underlying condition with diabetic chronic kidney disease | 1 |
| E08.29 | Diabetes mellitus due to underlying condition with other diabetic kidney complication | 1 |
| E08.311 | Diabetes mellitus due to underlying condition with unspecified diabetic retinopathy with macular edema | 1 |
| E08.319 | Diabetes mellitus due to underlying condition with unspecified diabetic retinopathy without macular edema | 1 |
| E08.3211 | Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy with macular edema, right eye | 1 |
Showing 10 of 461. The full list, non-covered diagnoses and CSV export are in Caduvo.
What changed for E2100
- 2026-01-01: Average state fee (NU) rose 2.0%: $849.30 to $866.28
- 2026-01-01: Average state fee (RR) rose 2.0%: $86.02 to $87.74
- 2026-01-01: Average state fee (UE) rose 2.0%: $636.05 to $648.77
- 2002-01-01: E2100 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code E2100?
E2100 is the HCPCS Level II code for blood glucose monitor with integrated voice synthesizer. Short descriptor: "Bld glucose monitor w voice".
How much does Medicare pay for E2100?
Under the 2026 DMEPOS fee schedule, non-rural state fees are NU (new equipment, purchased): $650.29–$1,084.76; RR (rental (monthly)): $76.49–$135.63; UE (used equipment, purchased): $440.60–$813.58. Rural fees can be higher.
Does Medicare cover E2100?
Coverage code D — Special coverage instructions apply. Medicare covers it when its national or local coverage criteria are met.
Which diagnoses support coverage for E2100?
Medicare policy articles that cite E2100 list 461 covered ICD-10-CM diagnosis codes across 1 article. The most cited include E08.00 (Diabetes mellitus due to underlying condition with hyperosmolarity without nonketotic hyperglycemic-hyperosmolar coma (NKHHC)), E08.01 (Diabetes mellitus due to underlying condition with hyperosmolarity with coma), E08.10 (Diabetes mellitus due to underlying condition with ketoacidosis without coma). A listed diagnosis is necessary but not sufficient; the policy's other criteria still apply.
Did the Medicare fee for E2100 change in 2026?
The average non-rural state fee for NU moved from $849.30 in 2025 to $866.28 in 2026 (+2.0%). CMS's next quarterly HCPCS and DMEPOS update takes effect January 1, 2027.
How many units of E2100 can be billed per day?
1 on DME suppliers (NCCI medically unlikely edits).
Related E21 codes
- E2101 — Blood glucose monitor with integrated lancing/blood sample ($26.88–$322.42)
- E2102 — Adjunctive, non-implanted continuous glucose monitor or receiver ($18.92–$239.22)
- E2103 — Non-adjunctive, non-implanted continuous glucose monitor or receiver ($25.61–$334.44)
- E2104 — Home blood glucose monitor for use with integrated lancing/blood sample testing cartridge ($5.47–$54.52)
- E2120 — Pulse generator system for tympanic treatment of inner ear endolymphatic fluid ($404.05–$484.90)
Building a device that would bill under a code like this? Caduvo matches a device description to HCPCS/CPT codes, Medicare coverage and payment, and the FDA pathway in one report.
Next steps
- Run a reimbursement report for a device billed under E2100
- Watch E2100 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for E2100
Sources: CMS HCPCS Level II release October 2026; CMS DMEPOS fee schedule 2026; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.