E2101 HCPCS code: Blood glucose monitor with integrated lancing/blood sample

E2101 is the HCPCS Level II code for blood glucose monitor with integrated lancing/blood sample. The 2026 Medicare DMEPOS fee schedule pays $268.71 to $322.42 (NU, new equipment, purchased) depending on the state. Its Medicare coverage code is D (Special coverage instructions apply): Medicare covers it when its national or local coverage criteria are met. The NCCI unit limit is 1 per day on DME suppliers. Medicare volume fell 37% from 2022 to 2023 (19 to 12 services). In 2023, 3 suppliers billed Medicare for E2101 (purchases), serving 12 beneficiaries. Its average fee ranks 3 of 5 E21 codes billed NU (family range $54.52–$866.28).

Code details

2026 Medicare DMEPOS fee schedule for E2101

How the E2101 fee compares

Who bills E2101 (2023)

Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.

Medicare utilization for E2101, 2022–2023

NCCI unit limits (MUE)

Medicare policy articles for this code

• A52464: Glucose Monitor - Policy Article (CGS Administrators, LLC (DME MAC) Noridian Healthcare Solutions, LLC (DME MAC)) — mentions this code in its coding guidance

Covered diagnoses (461 ICD-10-CM codes)

The diagnoses most often listed as covered in the policy articles above:

Showing 10 of 461. The full list, non-covered diagnoses and CSV export are in Caduvo.

What changed for E2101

• 2026-01-01: Average state fee (NU) rose 2.0%: $264.43 to $269.72
• 2026-01-01: Average state fee (RR) rose 2.0%: $26.45 to $26.98
• 2026-01-01: Average state fee (UE) rose 2.0%: $198.34 to $202.30
• 2002-01-01: E2101 added to HCPCS Level II
• Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01

Frequently asked questions

What is HCPCS code E2101?

E2101 is the HCPCS Level II code for blood glucose monitor with integrated lancing/blood sample. Short descriptor: "Bld glucose monitor w lance".

How much does Medicare pay for E2101?

Under the 2026 DMEPOS fee schedule, non-rural state fees are NU (new equipment, purchased): $268.71–$322.42; RR (rental (monthly)): $26.88–$32.25; UE (used equipment, purchased): $201.54–$241.84. Rural fees can be higher.

Does Medicare cover E2101?

Coverage code D — Special coverage instructions apply. Medicare covers it when its national or local coverage criteria are met.

Which diagnoses support coverage for E2101?

Medicare policy articles that cite E2101 list 461 covered ICD-10-CM diagnosis codes across 1 article. The most cited include E08.00 (Diabetes mellitus due to underlying condition with hyperosmolarity without nonketotic hyperglycemic-hyperosmolar coma (NKHHC)), E08.01 (Diabetes mellitus due to underlying condition with hyperosmolarity with coma), E08.10 (Diabetes mellitus due to underlying condition with ketoacidosis without coma). A listed diagnosis is necessary but not sufficient; the policy's other criteria still apply.

Did the Medicare fee for E2101 change in 2026?

The average non-rural state fee for NU moved from $264.43 in 2025 to $269.72 in 2026 (+2.0%). CMS's next quarterly HCPCS and DMEPOS update takes effect January 1, 2027.

How many units of E2101 can be billed per day?

1 on DME suppliers (NCCI medically unlikely edits).

Related E21 codes

• E2100 — Blood glucose monitor with integrated voice synthesizer ($76.49–$1,084.76)
• E2102 — Adjunctive, non-implanted continuous glucose monitor or receiver ($18.92–$239.22)
• E2103 — Non-adjunctive, non-implanted continuous glucose monitor or receiver ($25.61–$334.44)
• E2104 — Home blood glucose monitor for use with integrated lancing/blood sample testing cartridge ($5.47–$54.52)
• E2120 — Pulse generator system for tympanic treatment of inner ear endolymphatic fluid ($404.05–$484.90)

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Next steps

• Run a reimbursement report for a device billed under E2101
• Watch E2101 for fee, coverage and descriptor changes
• Build a full Medicare revenue model for E2101

Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule 2026; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.

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