J2250 HCPCS code: Injection, midazolam hydrochloride, per 1 mg
J2250 is the HCPCS Level II code for injection, midazolam hydrochloride, per 1 mg. In 2024 Medicare paid an average of $0.10 per service for J2250 across 258,501 services. Its Medicare coverage code is D (Special coverage instructions apply): Medicare covers it when its national or local coverage criteria are met. The NCCI unit limit is 30 per day on outpatient hospital claims. Medicare volume fell 27% from 2022 to 2024 (356,126 to 258,501 services). In 2024, about 2,555 clinicians billed Medicare for J2250 for 61,083 beneficiaries; Texas, California, Illinois accounted for 31% of services.
Code details
| Field | Value |
|---|---|
| Section | J codes — Drugs administered other than oral method |
| Coverage code | D — Special coverage instructions apply |
| Pricing indicator | 51 — Drug or biological (priced per ASP/average sales price rules) |
| BETOS category | O1E — Other drugs |
| Added | 1996-01-01 |
| Last action effective | 1997-01-01 |
Who bills J2250 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 2,555 |
| Medicare beneficiaries | 61,083 |
| States with claims | 49 |
| Share of services in top 3 states (Texas, California, Illinois) | 31% |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for J2250, 2022–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 356,126 | 78,049 | $0.14 | $0.11 |
| 2023 | 301,757 | 69,313 | $0.15 | $0.12 |
| 2024 | 258,501 | 61,083 | $0.13 | $0.10 |
States with the most J2250 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| Texas | 35,681 | $0.11 |
| California | 23,315 | $0.10 |
| Illinois | 20,489 | $0.11 |
| Oklahoma | 15,582 | $0.10 |
| Florida | 15,267 | $0.11 |
NCCI unit limits (MUE)
| Claim type | Max units per day | Rationale |
|---|---|---|
| outpatient hospital claims | 30 | Clinical: Data |
| practitioner claims | 22 | Clinical: Data |
What changed for J2250
- 1996-01-01: J2250 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code J2250?
J2250 is the HCPCS Level II code for injection, midazolam hydrochloride, per 1 mg. Short descriptor: "Inj midazolam hydrochloride".
How much does Medicare pay for J2250?
In 2024, the average Medicare payment was $0.10 per service (average allowed $0.13).
Does Medicare cover J2250?
Coverage code D — Special coverage instructions apply. Medicare covers it when its national or local coverage criteria are met.
How many units of J2250 can be billed per day?
30 on outpatient hospital claims; 22 on practitioner claims (NCCI medically unlikely edits).
Related J22 codes
- J2210 — Injection, methylergonovine maleate, up to 0.2 mg
- J2212 — Injection, methylnaltrexone, 0.1 mg
- J2246 — Injection, micafungin in sodium (baxter), not therapeutically equivalent to j2248, 1 mg
- J2247 — Injection, micafungin sodium (par pharm) not thereapeutically equivalent to j2248, 1 mg
- J2248 — Injection, micafungin sodium, 1 mg
- J2249 — Injection, remimazolam, 1 mg
- J2251 — Injection, midazolam in 0.9% sodium chloride, intravenous, not therapeutically equivalent to j2250, 1 mg
- J2252 — Injection, midazolam in 0.8% sodium chloride, intravenous, not therapeutically equivalent to j2250, 1 mg
- J2253 — Injection, midazolam (seizalam), 1 mg
- J2260 — Injection, milrinone lactate, 5 mg
- J2265 — Injection, minocycline hydrochloride, 1 mg
- J2267 — Injection, mirikizumab-mrkz, 1 mg
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Next steps
- Run a reimbursement report for a device billed under J2250
- Watch J2250 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for J2250
Sources: CMS HCPCS Level II release October 2026; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.