J2543 HCPCS code: Injection, piperacillin sodium/tazobactam sodium, 1 gram/0.125 grams (1.125 grams)
J2543 is the HCPCS Level II code for injection, piperacillin sodium/tazobactam sodium, 1 gram/0.125 grams (1.125 grams). In 2024 Medicare paid an average of $0.87 per service for J2543 across 39,989 services. Its Medicare coverage code is D (Special coverage instructions apply): Medicare covers it when its national or local coverage criteria are met. The NCCI unit limit is 20 per day on outpatient hospital claims. Medicare volume fell 12% from 2022 to 2024 (45,635 to 39,989 services). In 2024, about 521 clinicians billed Medicare for J2543 for 953 beneficiaries; Florida, North Carolina, Texas accounted for 61% of services.
Code details
| Field | Value |
|---|---|
| Section | J codes — Drugs administered other than oral method |
| Coverage code | D — Special coverage instructions apply |
| Pricing indicator | 51 — Drug or biological (priced per ASP/average sales price rules) |
| BETOS category | O1E — Other drugs |
| Added | 2000-01-01 |
| Last action effective | 2001-01-01 |
Who bills J2543 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 521 |
| Medicare beneficiaries | 953 |
| States with claims | 19 |
| Share of services in top 3 states (Florida, North Carolina, Texas) | 61% |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for J2543, 2022–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 45,635 | 867 | $1.36 | $1.08 |
| 2023 | 37,351 | 1,032 | $1.25 | $1.00 |
| 2024 | 39,989 | 953 | $1.10 | $0.87 |
States with the most J2543 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| Florida | 7,774 | $0.86 |
| North Carolina | 6,190 | $0.89 |
| Texas | 5,658 | $0.86 |
| New Jersey | 2,822 | $0.87 |
| California | 2,205 | $0.87 |
NCCI unit limits (MUE)
| Claim type | Max units per day | Rationale |
|---|---|---|
| outpatient hospital claims | 20 | Prescribing Information |
| practitioner claims | 16 | Prescribing Information |
What changed for J2543
- 2000-01-01: J2543 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code J2543?
J2543 is the HCPCS Level II code for injection, piperacillin sodium/tazobactam sodium, 1 gram/0.125 grams (1.125 grams). Short descriptor: "Piperacillin/tazobactam".
How much does Medicare pay for J2543?
In 2024, the average Medicare payment was $0.87 per service (average allowed $1.10).
Does Medicare cover J2543?
Coverage code D — Special coverage instructions apply. Medicare covers it when its national or local coverage criteria are met.
How many units of J2543 can be billed per day?
20 on outpatient hospital claims; 16 on practitioner claims (NCCI medically unlikely edits).
Related J25 codes
- J2501 — Injection, paricalcitol, 1 mcg
- J2502 — Injection, pasireotide long acting, 1 mg
- J2503 — Injection, pegaptanib sodium, 0.3 mg
- J2504 — Injection, pegademase bovine, 25 iu
- J2505 — Injection, pegfilgrastim, 6 mg
- J2506 — Injection, pegfilgrastim, excludes biosimilar, 0.5 mg
- J2507 — Injection, pegloticase, 1 mg
- J2508 — Injection, pegunigalsidase alfa-iwxj, 1 mg
- J2510 — Injection, penicillin g procaine, aqueous, up to 600,000 units
- J2513 — Injection, pentastarch, 10% solution, 100 ml
- J2515 — Injection, pentobarbital sodium, per 50 mg
- J2516 — Injection, pentamidine isethionate, 1 mg
Building a device that would bill under a code like this? Caduvo matches a device description to HCPCS/CPT codes, Medicare coverage and payment, and the FDA pathway in one report.
Next steps
- Run a reimbursement report for a device billed under J2543
- Watch J2543 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for J2543
Sources: CMS HCPCS Level II release October 2026; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.