J2545 HCPCS code: Pentamidine isethionate, inhalation solution, fda-approved final product, non-compounded, administered through dme, unit dose form, per 300 mg
J2545 is the HCPCS Level II code for pentamidine isethionate, inhalation solution, fda-approved final product, non-compounded, administered through dme, unit dose form, per 300 mg. In 2024 Medicare paid an average of $58.50 per service for J2545 across 1,370 services. Its Medicare coverage code is D (Special coverage instructions apply): Medicare covers it when its national or local coverage criteria are met. The NCCI unit limit is 3 per day on DME suppliers. Medicare volume rose 42% from 2022 to 2024 (966 to 1,370 services). In 2024, about 133 clinicians billed Medicare for J2545 for 424 beneficiaries.
Code details
| Field | Value |
|---|---|
| Section | J codes — Drugs administered other than oral method |
| Coverage code | D — Special coverage instructions apply |
| Pricing indicator | 51 — Drug or biological (priced per ASP/average sales price rules) |
| BETOS category | D1G — Drugs administered through DME |
| Added | 1992-01-01 |
| Last action effective | 2008-01-01 |
Who bills J2545 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 133 |
| Medicare beneficiaries | 424 |
| States with claims | 3 |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for J2545, 2022–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 966 | 313 | $114.92 | $87.82 |
| 2023 | 1,267 | 368 | $91.55 | $69.84 |
| 2024 | 1,370 | 424 | $75.72 | $58.50 |
States with the most J2545 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| Arizona | 488 | $58.69 |
| Florida | 411 | $57.97 |
| Minnesota | 336 | $58.40 |
NCCI unit limits (MUE)
| Claim type | Max units per day | Rationale |
|---|---|---|
| DME suppliers | 3 | Prescribing Information |
| outpatient hospital claims | 1 | Prescribing Information |
| practitioner claims | 1 | Prescribing Information |
What changed for J2545
- 1992-01-01: J2545 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code J2545?
J2545 is the HCPCS Level II code for pentamidine isethionate, inhalation solution, fda-approved final product, non-compounded, administered through dme, unit dose form, per 300 mg. Short descriptor: "Pentamidine non-comp unit".
How much does Medicare pay for J2545?
In 2024, the average Medicare payment was $58.50 per service (average allowed $75.72).
Does Medicare cover J2545?
Coverage code D — Special coverage instructions apply. Medicare covers it when its national or local coverage criteria are met.
How many units of J2545 can be billed per day?
3 on DME suppliers; 1 on outpatient hospital claims; 1 on practitioner claims (NCCI medically unlikely edits).
Related J25 codes
- J2501 — Injection, paricalcitol, 1 mcg
- J2502 — Injection, pasireotide long acting, 1 mg
- J2503 — Injection, pegaptanib sodium, 0.3 mg
- J2504 — Injection, pegademase bovine, 25 iu
- J2505 — Injection, pegfilgrastim, 6 mg
- J2506 — Injection, pegfilgrastim, excludes biosimilar, 0.5 mg
- J2507 — Injection, pegloticase, 1 mg
- J2508 — Injection, pegunigalsidase alfa-iwxj, 1 mg
- J2510 — Injection, penicillin g procaine, aqueous, up to 600,000 units
- J2513 — Injection, pentastarch, 10% solution, 100 ml
- J2515 — Injection, pentobarbital sodium, per 50 mg
- J2540 — Injection, penicillin g potassium, up to 600,000 units
Building a device that would bill under a code like this? Caduvo matches a device description to HCPCS/CPT codes, Medicare coverage and payment, and the FDA pathway in one report.
Next steps
- Run a reimbursement report for a device billed under J2545
- Watch J2545 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for J2545
Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.