J2850 HCPCS code: Injection, secretin, synthetic, human, 1 microgram
J2850 is the HCPCS Level II code for injection, secretin, synthetic, human, 1 microgram. In 2024 Medicare paid an average of $26.36 per service for J2850 across 466 services. Its Medicare coverage code is D (Special coverage instructions apply): Medicare covers it when its national or local coverage criteria are met. The NCCI unit limit is 48 per day on outpatient hospital claims. Medicare volume rose 11% from 2022 to 2024 (418 to 466 services). In 2024, about 30 clinicians billed Medicare for J2850 for 31 beneficiaries.
Code details
| Field | Value |
|---|---|
| Section | J codes — Drugs administered other than oral method |
| Coverage code | D — Special coverage instructions apply |
| Pricing indicator | 51 — Drug or biological (priced per ASP/average sales price rules) |
| BETOS category | O1E — Other drugs |
| Added | 2006-01-01 |
| Last action effective | 2006-01-01 |
Who bills J2850 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 30 |
| Medicare beneficiaries | 31 |
| States with claims | 1 |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for J2850, 2022–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 418 | 28 | $24.94 | $19.91 |
| 2023 | 598 | 37 | $27.89 | $22.22 |
| 2024 | 466 | 31 | $32.93 | $26.36 |
States with the most J2850 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| Minnesota | 240 | $25.71 |
NCCI unit limits (MUE)
| Claim type | Max units per day | Rationale |
|---|---|---|
| outpatient hospital claims | 48 | Clinical: Data |
| practitioner claims | 16 | Clinical: Data |
What changed for J2850
- 2006-01-01: J2850 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code J2850?
J2850 is the HCPCS Level II code for injection, secretin, synthetic, human, 1 microgram. Short descriptor: "Inj secretin synthetic human".
How much does Medicare pay for J2850?
In 2024, the average Medicare payment was $26.36 per service (average allowed $32.93).
Does Medicare cover J2850?
Coverage code D — Special coverage instructions apply. Medicare covers it when its national or local coverage criteria are met.
How many units of J2850 can be billed per day?
48 on outpatient hospital claims; 16 on practitioner claims (NCCI medically unlikely edits).
Related J28 codes
- J2800 — Injection, methocarbamol, up to 10 ml
- J2801 — Injection, risperidone (rykindo), 0.5 mg
- J2802 — Injection, romiplostim, 1 microgram
- J2804 — Injection, rifampin, 1 mg
- J2805 — Injection, sincalide, 5 micrograms
- J2806 — Injection, sincalide (maia), not therapeutically equivalent to j2805, 5 micrograms
- J2810 — Injection, theophylline, per 40 mg
- J2820 — Injection, sargramostim (gm-csf), 50 mcg
- J2840 — Injection, sebelipase alfa, 1 mg
- J2860 — Injection, siltuximab, 10 mg
- J2865 — Injection, sulfamethoxazole 5 mg and trimethoprim 1 mg
Building a device that would bill under a code like this? Caduvo matches a device description to HCPCS/CPT codes, Medicare coverage and payment, and the FDA pathway in one report.
Next steps
- Run a reimbursement report for a device billed under J2850
- Watch J2850 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for J2850
Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.