Q4221 HCPCS code: Amniowrap2, per square centimeter (add-on, list separately in addition to primary procedure)
Q4221 is the HCPCS Level II code for amniowrap2, per square centimeter (add-on, list separately in addition to primary procedure). In 2024 Medicare paid an average of $1,398.80 per service for Q4221 across 104,926 services. Its Medicare coverage code is C (Carrier judgment): Coverage is decided by the Medicare contractor (MAC) case by case. Medicare volume rose 4448% from 2022 to 2024 (2,307 to 104,926 services). In 2024, about 296 clinicians billed Medicare for Q4221 for 1,012 beneficiaries; California, Washington, Nevada accounted for 37% of services.
Code details
| Field | Value |
|---|---|
| Section | Q codes — Temporary codes |
| Coverage code | C — Carrier judgment |
| Pricing indicator | 11 — Priced using national relative value units (Physician Fee Schedule) |
| BETOS category | O1E — Other drugs |
| Added | 2019-10-01 |
| Last action effective | 2026-01-01 |
Who bills Q4221 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 296 |
| Medicare beneficiaries | 1,012 |
| States with claims | 19 |
| Share of services in top 3 states (California, Washington, Nevada) | 37% |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for Q4221, 2022–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 2,307 | 61 | $1,097.63 | $875.46 |
| 2023 | 19,324 | 374 | $1,391.42 | $1,108.46 |
| 2024 | 104,926 | 1,012 | $1,755.69 | $1,398.80 |
States with the most Q4221 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| California | 12,380 | $1,415.32 |
| Washington | 12,338 | $1,477.06 |
| Nevada | 12,244 | $1,285.20 |
| Texas | 10,834 | $1,392.68 |
| Arizona | 10,426 | $1,353.77 |
What changed for Q4221
- January 2026: Descriptor revised (Was: Amniowrap2, per square centimeter)
- 2019-10-01: Q4221 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code Q4221?
Q4221 is the HCPCS Level II code for amniowrap2, per square centimeter (add-on, list separately in addition to primary procedure). Short descriptor: "Amniowrap2 per sq cm".
How much does Medicare pay for Q4221?
In 2024, the average Medicare payment was $1,398.80 per service (average allowed $1,755.69).
Does Medicare cover Q4221?
Coverage code C — Carrier judgment. Coverage is decided by the Medicare contractor (MAC) case by case.
Related Q42 codes
- Q4200 — Skin te, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4201 — Matrion, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4202 — Keroxx (2.5g/cc), 1cc
- Q4203 — Derma-gide, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4204 — Xwrap, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4205 — Membrane graft or membrane wrap, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4206 — Fluid flow or fluid gf, 1 cc
- Q4207 — Carbon life, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4208 — Novafix, per square cenitmeter (add-on, list separately in addition to primary procedure)
- Q4209 — Surgraft, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4210 — Axolotl graft or axolotl dualgraft, per square centimeter
- Q4211 — Amnion bio or axobiomembrane, per square centimeter (add-on, list separately in addition to primary procedure)
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Next steps
- Run a reimbursement report for a device billed under Q4221
- Watch Q4221 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for Q4221
Sources: CMS HCPCS Level II release October 2026; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.