Q4222 HCPCS code: Progenamatrix, per square centimeter
Q4222 is the HCPCS Level II code for progenamatrix, per square centimeter. In 2024 Medicare paid an average of $80.49 per service for Q4222 across 6,319 services. Its Medicare coverage code is C (Carrier judgment): Coverage is decided by the Medicare contractor (MAC) case by case. Medicare volume rose 56% from 2022 to 2024 (4,046 to 6,319 services). In 2024, about 47 clinicians billed Medicare for Q4222 for 92 beneficiaries.
Code details
| Field | Value |
|---|---|
| Section | Q codes — Temporary codes |
| Coverage code | C — Carrier judgment |
| Pricing indicator | 51 — Drug or biological (priced per ASP/average sales price rules) |
| BETOS category | O1E — Other drugs |
| Added | 2019-10-01 |
| Last action effective | 2019-10-01 |
Who bills Q4222 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 47 |
| Medicare beneficiaries | 92 |
| States with claims | 3 |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for Q4222, 2022–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 4,046 | 59 | $181.73 | $144.97 |
| 2023 | 11,516 | 144 | $116.93 | $93.14 |
| 2024 | 6,319 | 92 | $101.08 | $80.49 |
States with the most Q4222 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| Michigan | 2,027 | $73.27 |
| Texas | 1,845 | $79.19 |
| Washington | 1,326 | $90.39 |
What changed for Q4222
- 2019-10-01: Q4222 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code Q4222?
Q4222 is the HCPCS Level II code for progenamatrix, per square centimeter. Short descriptor: "Progenamatrix, per sq cm".
How much does Medicare pay for Q4222?
In 2024, the average Medicare payment was $80.49 per service (average allowed $101.08).
Does Medicare cover Q4222?
Coverage code C — Carrier judgment. Coverage is decided by the Medicare contractor (MAC) case by case.
Related Q42 codes
- Q4200 — Skin te, per square centimeter
- Q4201 — Matrion, per square centimeter
- Q4202 — Keroxx (2.5g/cc), 1cc
- Q4203 — Derma-gide, per square centimeter
- Q4204 — Xwrap, per square centimeter
- Q4205 — Membrane graft or membrane wrap, per square centimeter
- Q4206 — Fluid flow or fluid gf, 1 cc
- Q4208 — Novafix, per square cenitmeter
- Q4209 — Surgraft, per square centimeter
- Q4210 — Axolotl graft or axolotl dualgraft, per square centimeter
- Q4211 — Amnion bio or axobiomembrane, per square centimeter
- Q4212 — Allogen, per cc
Building a device that would bill under a code like this? Caduvo matches a device description to HCPCS/CPT codes, Medicare coverage and payment, and the FDA pathway in one report.
Next steps
- Run a reimbursement report for a device billed under Q4222
- Watch Q4222 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for Q4222
Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.