Q4249 HCPCS code: Amniply, for topical use only, per square centimeter
Q4249 is the HCPCS Level II code for amniply, for topical use only, per square centimeter. In 2024 Medicare paid an average of $586.25 per service for Q4249 across 3,906 services. Its Medicare coverage code is C (Carrier judgment): Coverage is decided by the Medicare contractor (MAC) case by case. Medicare volume fell 58% from 2022 to 2024 (9,299 to 3,906 services). In 2024, about 20 clinicians billed Medicare for Q4249 for 73 beneficiaries.
Code details
| Field | Value |
|---|---|
| Section | Q codes — Temporary codes |
| Coverage code | C — Carrier judgment |
| Pricing indicator | 51 — Drug or biological (priced per ASP/average sales price rules) |
| BETOS category | O1E — Other drugs |
| Added | 2020-10-01 |
| Last action effective | 2020-10-01 |
Who bills Q4249 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 20 |
| Medicare beneficiaries | 73 |
| States with claims | 2 |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for Q4249, 2022–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 9,299 | 108 | $513.70 | $409.75 |
| 2023 | 24,840 | 653 | $604.11 | $481.30 |
| 2024 | 3,906 | 73 | $735.84 | $586.25 |
States with the most Q4249 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| Texas | 2,471 | $592.79 |
| Arkansas | 963 | $591.10 |
What changed for Q4249
- 2020-10-01: Q4249 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code Q4249?
Q4249 is the HCPCS Level II code for amniply, for topical use only, per square centimeter. Short descriptor: "Amniply, per sq cm".
How much does Medicare pay for Q4249?
In 2024, the average Medicare payment was $586.25 per service (average allowed $735.84).
Does Medicare cover Q4249?
Coverage code C — Carrier judgment. Coverage is decided by the Medicare contractor (MAC) case by case.
Related Q42 codes
- Q4200 — Skin te, per square centimeter
- Q4201 — Matrion, per square centimeter
- Q4202 — Keroxx (2.5g/cc), 1cc
- Q4203 — Derma-gide, per square centimeter
- Q4204 — Xwrap, per square centimeter
- Q4205 — Membrane graft or membrane wrap, per square centimeter
- Q4206 — Fluid flow or fluid gf, 1 cc
- Q4208 — Novafix, per square cenitmeter
- Q4209 — Surgraft, per square centimeter
- Q4210 — Axolotl graft or axolotl dualgraft, per square centimeter
- Q4211 — Amnion bio or axobiomembrane, per square centimeter
- Q4212 — Allogen, per cc
Building a device that would bill under a code like this? Caduvo matches a device description to HCPCS/CPT codes, Medicare coverage and payment, and the FDA pathway in one report.
Next steps
- Run a reimbursement report for a device billed under Q4249
- Watch Q4249 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for Q4249
Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.