Q4278 HCPCS code: Epieffect, per square centimeter
Q4278 is the HCPCS Level II code for epieffect, per square centimeter. In 2024 Medicare paid an average of $324.24 per service for Q4278 across 178,423 services. Its Medicare coverage code is C (Carrier judgment): Coverage is decided by the Medicare contractor (MAC) case by case. Medicare volume rose 919% from 2023 to 2024 (17,502 to 178,423 services). In 2024, about 672 clinicians billed Medicare for Q4278 for 2,391 beneficiaries; California, Minnesota, Florida accounted for 43% of services.
Code details
| Field | Value |
|---|---|
| Section | Q codes — Temporary codes |
| Coverage code | C — Carrier judgment |
| Pricing indicator | 51 — Drug or biological (priced per ASP/average sales price rules) |
| BETOS category | O1E — Other drugs |
| Added | 2023-07-01 |
| Last action effective | 2023-07-01 |
Who bills Q4278 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 672 |
| Medicare beneficiaries | 2,391 |
| States with claims | 29 |
| Share of services in top 3 states (California, Minnesota, Florida) | 43% |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for Q4278, 2023–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2023 | 17,502 | 351 | $515.56 | $410.77 |
| 2024 | 178,423 | 2,391 | $407.02 | $324.24 |
States with the most Q4278 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| California | 34,237 | $322.83 |
| Minnesota | 25,244 | $317.58 |
| Florida | 14,175 | $341.81 |
| Arizona | 10,399 | $329.35 |
| Washington | 10,325 | $333.57 |
What changed for Q4278
- 2023-07-01: Q4278 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code Q4278?
Q4278 is the HCPCS Level II code for epieffect, per square centimeter. Short descriptor: "Epieffect, per sq cm".
How much does Medicare pay for Q4278?
In 2024, the average Medicare payment was $324.24 per service (average allowed $407.02).
Does Medicare cover Q4278?
Coverage code C — Carrier judgment. Coverage is decided by the Medicare contractor (MAC) case by case.
Related Q42 codes
- Q4200 — Skin te, per square centimeter
- Q4201 — Matrion, per square centimeter
- Q4202 — Keroxx (2.5g/cc), 1cc
- Q4203 — Derma-gide, per square centimeter
- Q4204 — Xwrap, per square centimeter
- Q4205 — Membrane graft or membrane wrap, per square centimeter
- Q4206 — Fluid flow or fluid gf, 1 cc
- Q4208 — Novafix, per square cenitmeter
- Q4209 — Surgraft, per square centimeter
- Q4210 — Axolotl graft or axolotl dualgraft, per square centimeter
- Q4211 — Amnion bio or axobiomembrane, per square centimeter
- Q4212 — Allogen, per cc
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Next steps
- Run a reimbursement report for a device billed under Q4278
- Watch Q4278 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for Q4278
Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.