Q4331 HCPCS code: Axolotl graft, per square centimeter
Q4331 is the HCPCS Level II code for axolotl graft, per square centimeter. In 2024 Medicare paid an average of $1,310.16 per service for Q4331 across 77,438 services. Its Medicare coverage code is C (Carrier judgment): Coverage is decided by the Medicare contractor (MAC) case by case. In 2024, about 13 clinicians billed Medicare for Q4331 for 260 beneficiaries.
Code details
| Field | Value |
|---|---|
| Section | Q codes — Temporary codes |
| Coverage code | C — Carrier judgment |
| Pricing indicator | 51 — Drug or biological (priced per ASP/average sales price rules) |
| BETOS category | O1E — Other drugs |
| Added | 2024-07-01 |
| Last action effective | 2024-07-01 |
Who bills Q4331 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 13 |
| Medicare beneficiaries | 260 |
| States with claims | 1 |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for Q4331, 2024–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2024 | 77,438 | 260 | $1,644.38 | $1,310.16 |
States with the most Q4331 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| Florida | 77,438 | $1,310.16 |
What changed for Q4331
- 2024-07-01: Q4331 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code Q4331?
Q4331 is the HCPCS Level II code for axolotl graft, per square centimeter. Short descriptor: "Axolotl graft, per sq cm".
How much does Medicare pay for Q4331?
In 2024, the average Medicare payment was $1,310.16 per service (average allowed $1,644.38).
Does Medicare cover Q4331?
Coverage code C — Carrier judgment. Coverage is decided by the Medicare contractor (MAC) case by case.
Related Q43 codes
- Q4300 — Acesso tl, per square centimeter
- Q4301 — Activate matrix, per square centimeter
- Q4302 — Complete aca, per square centimeter
- Q4303 — Complete aa, per square centimeter
- Q4304 — Grafix plus, per square centimeter
- Q4305 — American amnion ac tri-layer, per square centimeter
- Q4306 — American amnion ac, per square centimeter
- Q4307 — American amnion, per square centimeter
- Q4308 — Sanopellis, per square centimeter
- Q4309 — Via matrix, per square centimeter
- Q4310 — Procenta, per 100 mg
- Q4311 — Acesso, per square centimeter
Building a device that would bill under a code like this? Caduvo matches a device description to HCPCS/CPT codes, Medicare coverage and payment, and the FDA pathway in one report.
Next steps
- Run a reimbursement report for a device billed under Q4331
- Watch Q4331 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for Q4331
Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.