S2107 HCPCS code: Adoptive immunotherapy i.e. development of specific anti-tumor reactivity (e.g., tumor-infiltrating lymphocyte therapy) per course of treatment
S2107 is the HCPCS Level II code for adoptive immunotherapy i.e. development of specific anti-tumor reactivity (e.g., tumor-infiltrating lymphocyte therapy) per course of treatment. Its Medicare coverage code is I (Not payable by Medicare): Medicare does not pay separately under this code; another code applies.
Code details
| Field | Value |
|---|---|
| Section | S codes — Temporary national codes (non-Medicare) |
| Coverage code | I — Not payable by Medicare |
| Pricing indicator | 00 — Not separately priced by Medicare |
| BETOS category | Z2 |
| Added | 2002-04-01 |
| Last action effective | 2002-04-01 |
What changed for S2107
- 2002-04-01: S2107 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code S2107?
S2107 is the HCPCS Level II code for adoptive immunotherapy i.e. development of specific anti-tumor reactivity (e.g., tumor-infiltrating lymphocyte therapy) per course of treatment. Short descriptor: "Adoptive immunotherapy".
Does Medicare cover S2107?
Coverage code I — Not payable by Medicare. Medicare does not pay separately under this code; another code applies.
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Next steps
- Run a reimbursement report for a device billed under S2107
- Watch S2107 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for S2107
Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.