S3855 HCPCS code: Genetic testing for detection of mutations in the presenilin - 1 gene
S3855 is the HCPCS Level II code for genetic testing for detection of mutations in the presenilin - 1 gene. CMS terminated S3855 on 2014-12-31; do not bill it for later dates of service. Its Medicare coverage code is I (Not payable by Medicare): Medicare does not pay separately under this code; another code applies.
Code details
| Field | Value |
|---|---|
| Section | S codes — Temporary national codes (non-Medicare) |
| Coverage code | I — Not payable by Medicare |
| Pricing indicator | 00 — Not separately priced by Medicare |
| BETOS category | Z2 |
| Added | 2007-01-01 |
| Last action effective | 2015-01-01 |
| Terminated | 2014-12-31 |
What changed for S3855
- 2007-01-01: S3855 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code S3855?
S3855 is the HCPCS Level II code for genetic testing for detection of mutations in the presenilin - 1 gene. Short descriptor: "Gene test presenilin-1 gene".
Does Medicare cover S3855?
Coverage code I — Not payable by Medicare. Medicare does not pay separately under this code; another code applies.
Related S38 codes
- S3800 — Genetic testing for amyotrophic lateral sclerosis (als)
- S3840 — Dna analysis for germline mutations of the ret proto-oncogene for susceptibility to multiple endocrine neoplasia type 2
- S3841 — Genetic testing for retinoblastoma
- S3842 — Genetic testing for von hippel-lindau disease
- S3844 — Dna analysis of the connexin 26 gene (gjb2) for susceptibility to congenital, profound deafness
- S3845 — Genetic testing for alpha-thalassemia
- S3846 — Genetic testing for hemoglobin e beta-thalassemia
- S3849 — Genetic testing for niemann-pick disease
- S3850 — Genetic testing for sickle cell anemia
- S3852 — Dna analysis for apoe epsilon 4 allele for susceptibility to alzheimer's disease
- S3853 — Genetic testing for myotonic muscular dystrophy
- S3854 — Gene expression profiling panel for use in the management of breast cancer treatment
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Next steps
- Run a reimbursement report for a device billed under S3855
- Watch S3855 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for S3855
Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.