S5566 HCPCS code: Insulin cartridge for use in insulin delivery device other than pump; 300 units
S5566 is the HCPCS Level II code for insulin cartridge for use in insulin delivery device other than pump; 300 units. Its Medicare coverage code is I (Not payable by Medicare): Medicare does not pay separately under this code; another code applies.
Code details
| Field | Value |
|---|---|
| Section | S codes — Temporary national codes (non-Medicare) |
| Coverage code | I — Not payable by Medicare |
| Pricing indicator | 00 — Not separately priced by Medicare |
| BETOS category | Z2 |
| Added | 2003-10-01 |
| Last action effective | 2003-10-01 |
What changed for S5566
- 2003-10-01: S5566 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code S5566?
S5566 is the HCPCS Level II code for insulin cartridge for use in insulin delivery device other than pump; 300 units. Short descriptor: "Insulin cartridge 300 u".
Does Medicare cover S5566?
Coverage code I — Not payable by Medicare. Medicare does not pay separately under this code; another code applies.
Related S55 codes
- S5501 — Home infusion therapy, catheter care / maintenance, complex (more than one lumen), includes administrative services, professional pharmacy services, care coordination, and all necessary supplies and equipment (drugs and nursing visits coded separately), per diem
- S5502 — Home infusion therapy, catheter care / maintenance, implanted access device, includes administrative services, professional pharmacy services, care coordination and all necessary supplies and equipment, (drugs and nursing visits coded separately), per diem (use this code for interim maintenance of vascular access not currently in use)
- S5517 — Home infusion therapy, all supplies necessary for restoration of catheter patency or declotting
- S5518 — Home infusion therapy, all supplies necessary for catheter repair
- S5520 — Home infusion therapy, all supplies (including catheter) necessary for a peripherally inserted central venous catheter (picc) line insertion
- S5521 — Home infusion therapy, all supplies (including catheter) necessary for a midline catheter insertion
- S5522 — Home infusion therapy, insertion of peripherally inserted central venous catheter (picc), nursing services only (no supplies or catheter included)
- S5523 — Home infusion therapy, insertion of midline venous catheter, nursing services only (no supplies or catheter included)
- S5550 — Insulin, rapid onset, 5 units
- S5551 — Insulin, most rapid onset (lispro or aspart); 5 units
- S5552 — Insulin, intermediate acting (nph or lente); 5 units
- S5553 — Insulin, long acting; 5 units
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Next steps
- Run a reimbursement report for a device billed under S5566
- Watch S5566 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for S5566
Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.