J2182 HCPCS code: Injection, mepolizumab, 1 mg
J2182 is the HCPCS Level II code for injection, mepolizumab, 1 mg. In 2024 Medicare paid an average of $23.42 per service for J2182 across 4,987,291 services. Its Medicare coverage code is C (Carrier judgment): Coverage is decided by the Medicare contractor (MAC) case by case. The NCCI unit limit is 300 per day on outpatient hospital claims. Medicare volume rose 22% from 2022 to 2024 (4,085,969 to 4,987,291 services). In 2024, about 3,014 clinicians billed Medicare for J2182 for 5,165 beneficiaries; Florida, Texas, California accounted for 32% of services.
Code details
| Field | Value |
|---|---|
| Section | J codes — Drugs administered other than oral method |
| Coverage code | C — Carrier judgment |
| Pricing indicator | 51 — Drug or biological (priced per ASP/average sales price rules) |
| BETOS category | O1E — Other drugs |
| Added | 2017-01-01 |
| Last action effective | 2017-01-01 |
Who bills J2182 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 3,014 |
| Medicare beneficiaries | 5,165 |
| States with claims | 45 |
| Share of services in top 3 states (Florida, Texas, California) | 32% |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for J2182, 2022–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 4,085,969 | 4,736 | $28.34 | $22.55 |
| 2023 | 4,650,986 | 5,147 | $28.79 | $22.88 |
| 2024 | 4,987,291 | 5,165 | $29.47 | $23.42 |
States with the most J2182 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| Florida | 726,235 | $23.72 |
| Texas | 464,803 | $23.55 |
| California | 396,825 | $22.67 |
| Arizona | 227,020 | $23.48 |
| New York | 220,265 | $23.57 |
NCCI unit limits (MUE)
| Claim type | Max units per day | Rationale |
|---|---|---|
| outpatient hospital claims | 300 | Prescribing Information |
| practitioner claims | 300 | Prescribing Information |
What changed for J2182
- 2017-01-01: J2182 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code J2182?
J2182 is the HCPCS Level II code for injection, mepolizumab, 1 mg. Short descriptor: "Injection, mepolizumab, 1mg".
How much does Medicare pay for J2182?
In 2024, the average Medicare payment was $23.42 per service (average allowed $29.47).
Does Medicare cover J2182?
Coverage code C — Carrier judgment. Coverage is decided by the Medicare contractor (MAC) case by case.
How many units of J2182 can be billed per day?
300 on outpatient hospital claims; 300 on practitioner claims (NCCI medically unlikely edits).
Related J21 codes
- J2150 — Injection, mannitol, 25% in 50 ml
- J2151 — Injection, mannitol, 250 mg
- J2170 — Injection, mecasermin, 1 mg
- J2175 — Injection, meperidine hydrochloride, per 100 mg
- J2180 — Injection, meperidine and promethazine hcl, up to 50 mg
- J2183 — Injection, meropenem (wg critical care), not therapeutically equivalent to j2185, 100 mg
- J2184 — Injection, meropenem (b. braun), not therapeutically equivalent to j2185, 100 mg
- J2185 — Injection, meropenem, 100 mg
- J2186 — Injection, meropenem and vaborbactam, 10mg/10mg (20mg)
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Next steps
- Run a reimbursement report for a device billed under J2182
- Watch J2182 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for J2182
Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.