J2280 HCPCS code: Injection, moxifloxacin, 100 mg
J2280 is the HCPCS Level II code for injection, moxifloxacin, 100 mg. In 2024 Medicare paid an average of $6.88 per service for J2280 across 5,668 services. Its Medicare coverage code is C (Carrier judgment): Coverage is decided by the Medicare contractor (MAC) case by case. The NCCI unit limit is 4 per day on DME suppliers. Medicare volume rose 245% from 2022 to 2024 (1,645 to 5,668 services). In 2024, about 108 clinicians billed Medicare for J2280 for 3,455 beneficiaries; Florida, Texas, Nebraska accounted for 38% of services.
Code details
| Field | Value |
|---|---|
| Section | J codes — Drugs administered other than oral method |
| Coverage code | C — Carrier judgment |
| Pricing indicator | 51 — Drug or biological (priced per ASP/average sales price rules) |
| BETOS category | O1E — Other drugs |
| Added | 2004-01-01 |
| Last action effective | 2004-01-01 |
Who bills J2280 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 108 |
| Medicare beneficiaries | 3,455 |
| States with claims | 21 |
| Share of services in top 3 states (Florida, Texas, Nebraska) | 38% |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for J2280, 2022–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 1,645 | 1,023 | $9.21 | $7.34 |
| 2023 | 2,949 | 1,776 | $9.76 | $7.74 |
| 2024 | 5,668 | 3,455 | $8.66 | $6.88 |
States with the most J2280 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| Florida | 1,104 | $6.97 |
| Texas | 562 | $6.83 |
| Nebraska | 470 | $6.96 |
| Washington | 448 | $6.83 |
| Oklahoma | 434 | $6.88 |
NCCI unit limits (MUE)
| Claim type | Max units per day | Rationale |
|---|---|---|
| DME suppliers | 4 | Prescribing Information |
| outpatient hospital claims | 8 | Clinical: Data |
| practitioner claims | 4 | Prescribing Information |
What changed for J2280
- 2004-01-01: J2280 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code J2280?
J2280 is the HCPCS Level II code for injection, moxifloxacin, 100 mg. Short descriptor: "Inj, moxifloxacin 100 mg".
How much does Medicare pay for J2280?
In 2024, the average Medicare payment was $6.88 per service (average allowed $8.66).
Does Medicare cover J2280?
Coverage code C — Carrier judgment. Coverage is decided by the Medicare contractor (MAC) case by case.
How many units of J2280 can be billed per day?
4 on DME suppliers; 8 on outpatient hospital claims; 4 on practitioner claims (NCCI medically unlikely edits).
Related J22 codes
- J2210 — Injection, methylergonovine maleate, up to 0.2 mg
- J2212 — Injection, methylnaltrexone, 0.1 mg
- J2246 — Injection, micafungin in sodium (baxter), not therapeutically equivalent to j2248, 1 mg
- J2247 — Injection, micafungin sodium (par pharm) not thereapeutically equivalent to j2248, 1 mg
- J2248 — Injection, micafungin sodium, 1 mg
- J2249 — Injection, remimazolam, 1 mg
- J2250 — Injection, midazolam hydrochloride, per 1 mg
- J2251 — Injection, midazolam in 0.9% sodium chloride, intravenous, not therapeutically equivalent to j2250, 1 mg
- J2252 — Injection, midazolam in 0.8% sodium chloride, intravenous, not therapeutically equivalent to j2250, 1 mg
- J2253 — Injection, midazolam (seizalam), 1 mg
- J2260 — Injection, milrinone lactate, 5 mg
- J2265 — Injection, minocycline hydrochloride, 1 mg
Building a device that would bill under a code like this? Caduvo matches a device description to HCPCS/CPT codes, Medicare coverage and payment, and the FDA pathway in one report.
Next steps
- Run a reimbursement report for a device billed under J2280
- Watch J2280 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for J2280
Sources: CMS HCPCS Level II release October 2026; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.