J2300 HCPCS code: Injection, nalbuphine hydrochloride, per 10 mg
J2300 is the HCPCS Level II code for injection, nalbuphine hydrochloride, per 10 mg. In 2024 Medicare paid an average of $2.25 per service for J2300 across 1,928 services. Its Medicare coverage code is D (Special coverage instructions apply): Medicare covers it when its national or local coverage criteria are met. The NCCI unit limit is 10 per day on outpatient hospital claims. Medicare volume fell 65% from 2022 to 2024 (5,470 to 1,928 services). In 2024, about 178 clinicians billed Medicare for J2300 for 415 beneficiaries; Oklahoma, Michigan, California accounted for 61% of services.
Code details
| Field | Value |
|---|---|
| Section | J codes — Drugs administered other than oral method |
| Coverage code | D — Special coverage instructions apply |
| Pricing indicator | 51 — Drug or biological (priced per ASP/average sales price rules) |
| BETOS category | O1E — Other drugs |
| Added | 1996-01-01 |
| Last action effective | 1997-01-01 |
Who bills J2300 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 178 |
| Medicare beneficiaries | 415 |
| States with claims | 10 |
| Share of services in top 3 states (Oklahoma, Michigan, California) | 61% |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for J2300, 2022–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 5,470 | 970 | $2.71 | $2.07 |
| 2023 | 4,525 | 620 | $2.63 | $2.03 |
| 2024 | 1,928 | 415 | $2.94 | $2.25 |
States with the most J2300 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| Oklahoma | 688 | $2.38 |
| Michigan | 244 | $2.24 |
| California | 182 | $2.27 |
| South Carolina | 152 | $2.28 |
| North Carolina | 134 | $2.33 |
NCCI unit limits (MUE)
| Claim type | Max units per day | Rationale |
|---|---|---|
| outpatient hospital claims | 10 | Clinical: CMS Workgroup |
| practitioner claims | 4 | Clinical: CMS Workgroup |
What changed for J2300
- 1996-01-01: J2300 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code J2300?
J2300 is the HCPCS Level II code for injection, nalbuphine hydrochloride, per 10 mg. Short descriptor: "Inj nalbuphine hydrochloride".
How much does Medicare pay for J2300?
In 2024, the average Medicare payment was $2.25 per service (average allowed $2.94).
Does Medicare cover J2300?
Coverage code D — Special coverage instructions apply. Medicare covers it when its national or local coverage criteria are met.
How many units of J2300 can be billed per day?
10 on outpatient hospital claims; 4 on practitioner claims (NCCI medically unlikely edits).
Related J23 codes
- J2305 — Injection, nitroglycerin, 5 mg
- J2310 — Injection, naloxone hydrochloride, per 1 mg
- J2311 — Injection, naloxone hydrochloride (zimhi), 1 mg
- J2312 — Injection, naloxone hydrochloride, not otherwise specified, 0.01 mg
- J2313 — Injection, naloxone hydrochloride (zimhi), 0.01 mg
- J2315 — Injection, naltrexone, depot form, 1 mg
- J2320 — Injection, nandrolone decanoate, up to 50 mg
- J2323 — Injection, natalizumab, 1 mg
- J2325 — Injection, nesiritide, 0.1 mg
- J2326 — Injection, nusinersen, 0.1 mg
- J2327 — Injection, risankizumab-rzaa, intravenous, 1 mg
- J2329 — Injection, ublituximab-xiiy, 1mg
Building a device that would bill under a code like this? Caduvo matches a device description to HCPCS/CPT codes, Medicare coverage and payment, and the FDA pathway in one report.
Next steps
- Run a reimbursement report for a device billed under J2300
- Watch J2300 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for J2300
Sources: CMS HCPCS Level II release October 2026; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.