J2310 HCPCS code: Injection, naloxone hydrochloride, per 1 mg
J2310 is the HCPCS Level II code for injection, naloxone hydrochloride, per 1 mg. CMS terminated J2310 on 2025-06-30; do not bill it for later dates of service. In 2024 Medicare paid an average of $6.03 per service for J2310 across 116 services. Its Medicare coverage code is D (Special coverage instructions apply): Medicare covers it when its national or local coverage criteria are met. Medicare volume fell 44% from 2022 to 2024 (208 to 116 services). In 2024, about 59 clinicians billed Medicare for J2310 for 102 beneficiaries.
Code details
| Field | Value |
|---|---|
| Section | J codes — Drugs administered other than oral method |
| Coverage code | D — Special coverage instructions apply |
| Pricing indicator | 51 — Drug or biological (priced per ASP/average sales price rules) |
| BETOS category | O1E — Other drugs |
| Added | 1996-01-01 |
| Last action effective | 2025-07-01 |
| Terminated | 2025-06-30 |
Who bills J2310 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 59 |
| Medicare beneficiaries | 102 |
| States with claims | 2 |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for J2310, 2022–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 208 | 175 | $10.40 | $8.14 |
| 2023 | 161 | 127 | $8.95 | $7.08 |
| 2024 | 116 | 102 | $7.57 | $6.03 |
States with the most J2310 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| Oklahoma | 26 | $6.47 |
| Texas | 12 | $6.35 |
What changed for J2310
- 1996-01-01: J2310 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code J2310?
J2310 is the HCPCS Level II code for injection, naloxone hydrochloride, per 1 mg. Short descriptor: "Inj naloxone hydrochloride".
How much does Medicare pay for J2310?
In 2024, the average Medicare payment was $6.03 per service (average allowed $7.57).
Does Medicare cover J2310?
Coverage code D — Special coverage instructions apply. Medicare covers it when its national or local coverage criteria are met.
Related J23 codes
- J2300 — Injection, nalbuphine hydrochloride, per 10 mg
- J2305 — Injection, nitroglycerin, 5 mg
- J2311 — Injection, naloxone hydrochloride (zimhi), 1 mg
- J2312 — Injection, naloxone hydrochloride, not otherwise specified, 0.01 mg
- J2313 — Injection, naloxone hydrochloride (zimhi), 0.01 mg
- J2315 — Injection, naltrexone, depot form, 1 mg
- J2320 — Injection, nandrolone decanoate, up to 50 mg
- J2323 — Injection, natalizumab, 1 mg
- J2325 — Injection, nesiritide, 0.1 mg
- J2326 — Injection, nusinersen, 0.1 mg
- J2327 — Injection, risankizumab-rzaa, intravenous, 1 mg
- J2329 — Injection, ublituximab-xiiy, 1mg
Building a device that would bill under a code like this? Caduvo matches a device description to HCPCS/CPT codes, Medicare coverage and payment, and the FDA pathway in one report.
Next steps
- Run a reimbursement report for a device billed under J2310
- Watch J2310 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for J2310
Sources: CMS HCPCS Level II release October 2026; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.