Q4104 HCPCS code: Integra bilayer matrix wound dressing (bmwd), per square centimeter (add-on, list separately in addition to primary procedure)
Q4104 is the HCPCS Level II code for integra bilayer matrix wound dressing (bmwd), per square centimeter (add-on, list separately in addition to primary procedure). In 2024 Medicare paid an average of $38.67 per service for Q4104 across 1,121 services. Its Medicare coverage code is C (Carrier judgment): Coverage is decided by the Medicare contractor (MAC) case by case. Medicare volume rose 134% from 2023 to 2024 (480 to 1,121 services). In 2024, about 13 clinicians billed Medicare for Q4104 for 22 beneficiaries.
Code details
| Field | Value |
|---|---|
| Section | Q codes — Temporary codes |
| Coverage code | C — Carrier judgment |
| Pricing indicator | 11 — Priced using national relative value units (Physician Fee Schedule) |
| BETOS category | O1E — Other drugs |
| Added | 2009-01-01 |
| Last action effective | 2026-01-01 |
Who bills Q4104 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 13 |
| Medicare beneficiaries | 22 |
| States with claims | 0 |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for Q4104, 2023–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2023 | 480 | 12 | $47.63 | $37.95 |
| 2024 | 1,121 | 22 | $48.57 | $38.67 |
What changed for Q4104
- January 2026: Descriptor revised (Was: Integra bilayer matrix wound dressing (bmwd), per square centimeter)
- 2009-01-01: Q4104 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code Q4104?
Q4104 is the HCPCS Level II code for integra bilayer matrix wound dressing (bmwd), per square centimeter (add-on, list separately in addition to primary procedure). Short descriptor: "Integra bmwd".
How much does Medicare pay for Q4104?
In 2024, the average Medicare payment was $38.67 per service (average allowed $48.57).
Does Medicare cover Q4104?
Coverage code C — Carrier judgment. Coverage is decided by the Medicare contractor (MAC) case by case.
Related Q41 codes
- Q4100 — Skin substitute, not otherwise specified
- Q4101 — Apligraf, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4102 — Oasis wound matrix, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4103 — Oasis burn matrix, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4105 — Integra dermal regeneration template (drt) or integra omnigraft dermal regeneration matrix, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4106 — Dermagraft, per square centimeter
- Q4107 — Graftjacket, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4108 — Integra matrix, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4110 — Primatrix, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4111 — Gammagraft, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4112 — Cymetra, injectable, 1 cc
- Q4113 — Graftjacket xpress, injectable, 1 cc
Building a device that would bill under a code like this? Caduvo matches a device description to HCPCS/CPT codes, Medicare coverage and payment, and the FDA pathway in one report.
Next steps
- Run a reimbursement report for a device billed under Q4104
- Watch Q4104 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for Q4104
Sources: CMS HCPCS Level II release October 2026; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.