Q4105 HCPCS code: Integra dermal regeneration template (drt) or integra omnigraft dermal regeneration matrix, per square centimeter (add-on, list separately in addition to primary procedure)
Q4105 is the HCPCS Level II code for integra dermal regeneration template (drt) or integra omnigraft dermal regeneration matrix, per square centimeter (add-on, list separately in addition to primary procedure). Its Medicare coverage code is C (Carrier judgment): Coverage is decided by the Medicare contractor (MAC) case by case.
Code details
| Field | Value |
|---|---|
| Section | Q codes — Temporary codes |
| Coverage code | C — Carrier judgment |
| Pricing indicator | 11 — Priced using national relative value units (Physician Fee Schedule) |
| BETOS category | O1E — Other drugs |
| Added | 2009-01-01 |
| Last action effective | 2026-01-01 |
What changed for Q4105
- January 2026: Descriptor revised (Was: Integra dermal regeneration template (drt) or integra omnigraft dermal regeneration matrix, per square centimeter)
- 2009-01-01: Q4105 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code Q4105?
Q4105 is the HCPCS Level II code for integra dermal regeneration template (drt) or integra omnigraft dermal regeneration matrix, per square centimeter (add-on, list separately in addition to primary procedure). Short descriptor: "Integra drt or omnigraft".
Does Medicare cover Q4105?
Coverage code C — Carrier judgment. Coverage is decided by the Medicare contractor (MAC) case by case.
Related Q41 codes
- Q4100 — Skin substitute, not otherwise specified
- Q4101 — Apligraf, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4102 — Oasis wound matrix, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4103 — Oasis burn matrix, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4104 — Integra bilayer matrix wound dressing (bmwd), per square centimeter (add-on, list separately in addition to primary procedure)
- Q4106 — Dermagraft, per square centimeter
- Q4107 — Graftjacket, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4108 — Integra matrix, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4110 — Primatrix, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4111 — Gammagraft, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4112 — Cymetra, injectable, 1 cc
- Q4113 — Graftjacket xpress, injectable, 1 cc
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Next steps
- Run a reimbursement report for a device billed under Q4105
- Watch Q4105 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for Q4105
Sources: CMS HCPCS Level II release October 2026; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.