Q4110 HCPCS code: Primatrix, per square centimeter
Q4110 is the HCPCS Level II code for primatrix, per square centimeter. In 2023 Medicare paid an average of $33.11 per service for Q4110 across 1,978 services. Its Medicare coverage code is C (Carrier judgment): Coverage is decided by the Medicare contractor (MAC) case by case. Medicare volume fell 59% from 2022 to 2023 (4,774 to 1,978 services). In 2023, about 27 clinicians billed Medicare for Q4110 for 90 beneficiaries.
Code details
| Field | Value |
|---|---|
| Section | Q codes — Temporary codes |
| Coverage code | C — Carrier judgment |
| Pricing indicator | 51 — Drug or biological (priced per ASP/average sales price rules) |
| BETOS category | O1E — Other drugs |
| Added | 2009-01-01 |
| Last action effective | 2014-01-01 |
Who bills Q4110 (2023)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 27 |
| Medicare beneficiaries | 90 |
| States with claims | 4 |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for Q4110, 2022–2023
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 4,774 | 204 | $41.21 | $32.86 |
| 2023 | 1,978 | 90 | $41.56 | $33.11 |
States with the most Q4110 services (2023)
| State | Services | Avg. paid |
|---|---|---|
| North Carolina | 458 | $33.28 |
| California | 433 | $33.03 |
| Tennessee | 244 | $33.39 |
| Missouri | 176 | $32.84 |
What changed for Q4110
- 2009-01-01: Q4110 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code Q4110?
Q4110 is the HCPCS Level II code for primatrix, per square centimeter. Short descriptor: "Primatrix".
How much does Medicare pay for Q4110?
In 2023, the average Medicare payment was $33.11 per service (average allowed $41.56).
Does Medicare cover Q4110?
Coverage code C — Carrier judgment. Coverage is decided by the Medicare contractor (MAC) case by case.
Related Q41 codes
- Q4100 — Skin substitute, not otherwise specified
- Q4101 — Apligraf, per square centimeter
- Q4102 — Oasis wound matrix, per square centimeter
- Q4103 — Oasis burn matrix, per square centimeter
- Q4104 — Integra bilayer matrix wound dressing (bmwd), per square centimeter
- Q4105 — Integra dermal regeneration template (drt) or integra omnigraft dermal regeneration matrix, per square centimeter
- Q4106 — Dermagraft, per square centimeter
- Q4107 — Graftjacket, per square centimeter
- Q4108 — Integra matrix, per square centimeter
- Q4111 — Gammagraft, per square centimeter
- Q4112 — Cymetra, injectable, 1 cc
- Q4113 — Graftjacket xpress, injectable, 1 cc
Building a device that would bill under a code like this? Caduvo matches a device description to HCPCS/CPT codes, Medicare coverage and payment, and the FDA pathway in one report.
Next steps
- Run a reimbursement report for a device billed under Q4110
- Watch Q4110 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for Q4110
Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.