A52.03: Syphilitic endocarditis

A52.03, syphilitic endocarditis, is listed as a covered diagnosis in 5 Medicare billing and coding articles that apply to 21 HCPCS Level II codes, including J0461 (Injection, atropine sulfate, 0.01 mg), J0153 (Injection, adenosine, 1 mg (not to be used to report any…), J1250 (Injection, dobutamine hydrochloride, per 250 mg). The articles come from 3 Medicare contractors. A listed diagnosis supports medical necessity only; coverage still depends on the LCD's criteria and on documentation in the medical record.

HCPCS Level II codes with A52.03 as a covered diagnosis

Code	Description	Medicare coverage	DMEPOS fee 2026 (state range)	Articles listing it
J0461	Injection, atropine sulfate, 0.01 mg	Special coverage instructions apply	—	3
J0153	Injection, adenosine, 1 mg (not to be used to report any adenosine phosphate compounds)	Special coverage instructions apply	—	3
J1250	Injection, dobutamine hydrochloride, per 250 mg	Special coverage instructions apply	—	3
J0280	Injection, aminophyllin, up to 250 mg	Special coverage instructions apply	—	3
J1245	Injection, dipyridamole, per 10 mg	Special coverage instructions apply	—	3
A9700	Supply of injectable contrast material for use in echocardiography, per study	Special coverage instructions apply	—	3
G0278	Iliac and/or femoral artery angiography, non-selective, bilateral or ipsilateral to catheter insertion, performed at the same time as cardiac catheterization and/or coronary angiography, includes positioning or placement of the catheter in the distal aorta or ipsilateral femoral or iliac artery, injection of dye, production of permanent images, and radiologic supervision and interpretation (list separately in addition to primary procedure)	Carrier judgment	—	2
G0269	Placement of occlusive device into either a venous or arterial access site, post surgical or interventional procedure (e.g., angioseal plug, vascular plug)	Special coverage instructions apply	—	2
J2785	Injection, regadenoson, 0.1 mg	Carrier judgment	—	2
Q9957	Injection, perflutren lipid microspheres, per ml	Carrier judgment	—	2
Q9956	Injection, octafluoropropane microspheres, per ml	Carrier judgment	—	2
C8921	Transthoracic echocardiography with contrast, or without contrast followed by with contrast, for congenital cardiac anomalies; complete	Special coverage instructions apply	—	2
C8922	Transthoracic echocardiography with contrast, or without contrast followed by with contrast, for congenital cardiac anomalies; follow-up or limited study	Special coverage instructions apply	—	2
C8923	Transthoracic echocardiography with contrast, or without contrast followed by with contrast, real-time with image documentation (2d), includes m-mode recording, when performed, complete, without spectral or color doppler echocardiography	Special coverage instructions apply	—	2
C8924	Transthoracic echocardiography with contrast, or without contrast followed by with contrast, real-time with image documentation (2d), includes m-mode recording, when performed, follow-up or limited study	Special coverage instructions apply	—	2
C8928	Transthoracic echocardiography with contrast, or without contrast followed by with contrast, real-time with image documentation (2d), includes m-mode recording, when performed, during rest and cardiovascular stress test using treadmill, bicycle exercise and/or pharmacologically induced stress, with interpretation and report	Special coverage instructions apply	—	2
C8929	Transthoracic echocardiography with contrast, or without contrast followed by with contrast, real-time with image documentation (2d), includes m-mode recording, when performed, complete, with spectral doppler echocardiography, and with color flow doppler echocardiography	Special coverage instructions apply	—	2
C8930	Transthoracic echocardiography, with contrast, or without contrast followed by with contrast, real-time with image documentation (2d), includes m-mode recording, when performed, during rest and cardiovascular stress test using treadmill, bicycle exercise and/or pharmacologically induced stress, with interpretation and report; including performance of continuous electrocardiographic monitoring, with physician supervision	Special coverage instructions apply	—	2
Q9955	Injection, perflexane lipid microspheres, per ml	Carrier judgment	—	2
J3490	Unclassified drugs	Special coverage instructions apply	—	1
C9399	Unclassified drugs or biologicals	Special coverage instructions apply	—	1

Medicare policy articles listing A52.03

A56500: Billing and Coding: Cardiac Catheterization and Coronary Angiography (CGS Administrators, LLC (MAC - Part A, MAC - Part B); 2 Level II codes). LCD with the same title: L33557, L33959
A52850: Billing and Coding: Cardiac Catheterization and Coronary Angiography (Wellpoint Federal (MAC - Part A, MAC - Part B); 2 Level II codes). LCD with the same title: L33557, L33959
A57306: Billing and Coding: Transthoracic Echocardiography (TTE) (CGS Administrators, LLC (MAC - Part A, MAC - Part B); 19 Level II codes). LCD with the same title: L33577, L34338
A56781: Billing and Coding: Transthoracic Echocardiography (TTE) (Wellpoint Federal (MAC - Part A, MAC - Part B); 17 Level II codes). LCD with the same title: L33577, L34338
A56625: Billing and Coding: Echocardiography (Palmetto GBA (MAC - Part A, MAC - Part B); 6 Level II codes). LCD with the same title: L37379

A diagnosis listed as covered in a billing and coding article supports medical necessity for the article's codes; it does not guarantee payment. Coverage depends on the LCD's criteria, the contractor's jurisdiction and documentation in the medical record.

Other A52 diagnoses (Late syphilis)

A52.01 — Syphilitic aneurysm of aorta
A52.02 — Syphilitic aortitis
A52.06 — Other syphilitic heart involvement
A52.10 — Symptomatic neurosyphilis, unspecified
A52.11 — Tabes dorsalis
A52.13 — Late syphilitic meningitis
A52.14 — Late syphilitic encephalitis
A52.15 — Late syphilitic neuropathy
A52.16 — Charcot's arthropathy (tabetic)
A52.17 — General paresis
A52.19 — Other symptomatic neurosyphilis
A52.2 — Asymptomatic neurosyphilis
A52.3 — Neurosyphilis, unspecified
A52.76 — Other genitourinary symptomatic late syphilis

Frequently asked questions

Does Medicare cover A52.03 (Syphilitic endocarditis)?

Medicare covers items and services, not diagnoses. 5 Medicare billing and coding articles list A52.03 as a covered diagnosis for 21 HCPCS Level II codes: the diagnosis can support medical necessity for those codes, but payment still depends on the LCD's coverage criteria and the medical record.

Which HCPCS codes can be billed with ICD-10 A52.03?

The Level II codes from the policies most specific to this diagnosis are J0461 (Injection, atropine sulfate, 0.01 mg, 3 articles); J0153 (Injection, adenosine, 1 mg (not to be used to report any…, 3 articles); J1250 (Injection, dobutamine hydrochloride, per 250 mg, 3 articles); J0280 (Injection, aminophyllin, up to 250 mg, 3 articles); J1245 (Injection, dipyridamole, per 10 mg, 3 articles). Code choice depends on the item supplied; check each code's descriptor.

Which Medicare policy articles list A52.03?

A56500 (Billing and Coding: Cardiac Catheterization and Coronary Angiography); A52850 (Billing and Coding: Cardiac Catheterization and Coronary Angiography); A57306 (Billing and Coding: Transthoracic Echocardiography (TTE)), and 2 more articles.

What is ICD-10-CM code A52.03?

A52.03 is the ICD-10-CM code for syphilitic endocarditis, in category A52 (Late syphilis), chapter 1: Certain infectious and parasitic diseases.

Next steps

Sources: CMS Medicare Coverage Database billing and coding articles (covered ICD-10 code lists and HCPCS links); ICD-10-CM FY2026; CMS HCPCS Level II release October 2026; CMS DMEPOS fee schedule 2026 (non-rural state fees). Not billing or legal advice.

Chapter 1: Certain infectious and parasitic diseases · All diagnoses · HCPCS lookup