Q4159 HCPCS code: Affinity, per square centimeter
Q4159 is the HCPCS Level II code for affinity, per square centimeter. In 2024 Medicare paid an average of $248.93 per service for Q4159 across 48,990 services. Its Medicare coverage code is C (Carrier judgment): Coverage is decided by the Medicare contractor (MAC) case by case. Medicare volume fell 64% from 2022 to 2024 (137,264 to 48,990 services). In 2024, about 660 clinicians billed Medicare for Q4159 for 1,393 beneficiaries; California, Florida, Ohio accounted for 30% of services.
Code details
| Field | Value |
|---|---|
| Section | Q codes — Temporary codes |
| Coverage code | C — Carrier judgment |
| Pricing indicator | 51 — Drug or biological (priced per ASP/average sales price rules) |
| BETOS category | O1E — Other drugs |
| Added | 2015-01-01 |
| Last action effective | 2015-01-01 |
Who bills Q4159 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 660 |
| Medicare beneficiaries | 1,393 |
| States with claims | 30 |
| Share of services in top 3 states (California, Florida, Ohio) | 30% |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for Q4159, 2022–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2022 | 137,264 | 3,423 | $510.61 | $407.33 |
| 2023 | 122,294 | 3,029 | $406.49 | $323.80 |
| 2024 | 48,990 | 1,393 | $312.73 | $248.93 |
States with the most Q4159 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| California | 5,452 | $255.87 |
| Florida | 5,013 | $247.04 |
| Ohio | 3,710 | $240.11 |
| Utah | 3,221 | $259.95 |
| Illinois | 2,900 | $251.74 |
What changed for Q4159
- 2015-01-01: Q4159 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code Q4159?
Q4159 is the HCPCS Level II code for affinity, per square centimeter. Short descriptor: "Affinity1 square cm".
How much does Medicare pay for Q4159?
In 2024, the average Medicare payment was $248.93 per service (average allowed $312.73).
Does Medicare cover Q4159?
Coverage code C — Carrier judgment. Coverage is decided by the Medicare contractor (MAC) case by case.
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Building a device that would bill under a code like this? Caduvo matches a device description to HCPCS/CPT codes, Medicare coverage and payment, and the FDA pathway in one report.
Next steps
- Run a reimbursement report for a device billed under Q4159
- Watch Q4159 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for Q4159
Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.