Q4161 HCPCS code: Bio-connekt wound matrix, per square centimeter
Q4161 is the HCPCS Level II code for bio-connekt wound matrix, per square centimeter. In 2024 Medicare paid an average of $1,329.68 per service for Q4161 across 11,529 services. Its Medicare coverage code is C (Carrier judgment): Coverage is decided by the Medicare contractor (MAC) case by case. Medicare volume rose 288% from 2023 to 2024 (2,971 to 11,529 services). In 2024, about 94 clinicians billed Medicare for Q4161 for 239 beneficiaries; Texas, California, Oregon accounted for 89% of services.
Code details
| Field | Value |
|---|---|
| Section | Q codes — Temporary codes |
| Coverage code | C — Carrier judgment |
| Pricing indicator | 51 — Drug or biological (priced per ASP/average sales price rules) |
| BETOS category | O1E — Other drugs |
| Added | 2016-01-01 |
| Last action effective | 2016-01-01 |
Who bills Q4161 (2024)
| Measure | Value |
|---|---|
| Clinicians billing (by place of service) | 94 |
| Medicare beneficiaries | 239 |
| States with claims | 5 |
| Share of services in top 3 states (Texas, California, Oregon) | 89% |
Counts only. Supplier and clinician names, contact lists and state-by-state detail are in Caduvo.
Medicare utilization for Q4161, 2023–2024
| Year | Services | Beneficiaries | Avg. allowed | Avg. paid |
|---|---|---|---|---|
| 2023 | 2,971 | 96 | $132.25 | $105.31 |
| 2024 | 11,529 | 239 | $1,668.91 | $1,329.68 |
States with the most Q4161 services (2024)
| State | Services | Avg. paid |
|---|---|---|
| Texas | 4,190 | $1,474.27 |
| California | 2,842 | $1,014.57 |
| Oregon | 1,460 | $1,432.41 |
| Florida | 634 | $1,523.50 |
| Nevada | 457 | $1,257.55 |
What changed for Q4161
- 2016-01-01: Q4161 added to HCPCS Level II
- Next scheduled CMS quarterly update (HCPCS and DMEPOS fee schedule): 2027-01-01
Frequently asked questions
What is HCPCS code Q4161?
Q4161 is the HCPCS Level II code for bio-connekt wound matrix, per square centimeter. Short descriptor: "Bio-connekt per square cm".
How much does Medicare pay for Q4161?
In 2024, the average Medicare payment was $1,329.68 per service (average allowed $1,668.91).
Does Medicare cover Q4161?
Coverage code C — Carrier judgment. Coverage is decided by the Medicare contractor (MAC) case by case.
Related Q41 codes
- Q4100 — Skin substitute, not otherwise specified
- Q4101 — Apligraf, per square centimeter
- Q4102 — Oasis wound matrix, per square centimeter
- Q4103 — Oasis burn matrix, per square centimeter
- Q4104 — Integra bilayer matrix wound dressing (bmwd), per square centimeter
- Q4105 — Integra dermal regeneration template (drt) or integra omnigraft dermal regeneration matrix, per square centimeter
- Q4106 — Dermagraft, per square centimeter
- Q4107 — Graftjacket, per square centimeter
- Q4108 — Integra matrix, per square centimeter
- Q4110 — Primatrix, per square centimeter
- Q4111 — Gammagraft, per square centimeter
- Q4112 — Cymetra, injectable, 1 cc
Building a device that would bill under a code like this? Caduvo matches a device description to HCPCS/CPT codes, Medicare coverage and payment, and the FDA pathway in one report.
Next steps
- Run a reimbursement report for a device billed under Q4161
- Watch Q4161 for fee, coverage and descriptor changes
- Build a full Medicare revenue model for Q4161
Sources: CMS HCPCS Level II release October 2025; CMS DMEPOS fee schedule; CMS NCCI MUE tables; CMS Medicare utilization (physician and DME supplier files); CMS Medicare Coverage Database articles. Fees are Medicare allowables, not commercial rates. Not billing or legal advice.