R22.2: Localized swelling, mass and lump, trunk

R22.2, localized swelling, mass and lump, trunk, is listed as a covered diagnosis in 4 Medicare billing and coding articles that apply to 26 HCPCS Level II codes, including J2785 (Injection, regadenoson, 0.1 mg), J0461 (Injection, atropine sulfate, 0.01 mg), J0153 (Injection, adenosine, 1 mg (not to be used to report any…). The articles come from 3 Medicare contractors. A listed diagnosis supports medical necessity only; coverage still depends on the LCD's criteria and on documentation in the medical record.

HCPCS Level II codes with R22.2 as a covered diagnosis

Code	Description	Medicare coverage	DMEPOS fee 2026 (state range)	Articles listing it
J2785	Injection, regadenoson, 0.1 mg	Carrier judgment	—	2
J0461	Injection, atropine sulfate, 0.01 mg	Special coverage instructions apply	—	2
J0153	Injection, adenosine, 1 mg (not to be used to report any adenosine phosphate compounds)	Special coverage instructions apply	—	2
Q9957	Injection, perflutren lipid microspheres, per ml	Carrier judgment	—	2
J1250	Injection, dobutamine hydrochloride, per 250 mg	Special coverage instructions apply	—	2
J0280	Injection, aminophyllin, up to 250 mg	Special coverage instructions apply	—	2
J1245	Injection, dipyridamole, per 10 mg	Special coverage instructions apply	—	2
Q9956	Injection, octafluoropropane microspheres, per ml	Carrier judgment	—	2
A9700	Supply of injectable contrast material for use in echocardiography, per study	Special coverage instructions apply	—	2
C8921	Transthoracic echocardiography with contrast, or without contrast followed by with contrast, for congenital cardiac anomalies; complete	Special coverage instructions apply	—	2
C8922	Transthoracic echocardiography with contrast, or without contrast followed by with contrast, for congenital cardiac anomalies; follow-up or limited study	Special coverage instructions apply	—	2
C8923	Transthoracic echocardiography with contrast, or without contrast followed by with contrast, real-time with image documentation (2d), includes m-mode recording, when performed, complete, without spectral or color doppler echocardiography	Special coverage instructions apply	—	2
C8924	Transthoracic echocardiography with contrast, or without contrast followed by with contrast, real-time with image documentation (2d), includes m-mode recording, when performed, follow-up or limited study	Special coverage instructions apply	—	2
C8928	Transthoracic echocardiography with contrast, or without contrast followed by with contrast, real-time with image documentation (2d), includes m-mode recording, when performed, during rest and cardiovascular stress test using treadmill, bicycle exercise and/or pharmacologically induced stress, with interpretation and report	Special coverage instructions apply	—	2
C8929	Transthoracic echocardiography with contrast, or without contrast followed by with contrast, real-time with image documentation (2d), includes m-mode recording, when performed, complete, with spectral doppler echocardiography, and with color flow doppler echocardiography	Special coverage instructions apply	—	2
C8930	Transthoracic echocardiography, with contrast, or without contrast followed by with contrast, real-time with image documentation (2d), includes m-mode recording, when performed, during rest and cardiovascular stress test using treadmill, bicycle exercise and/or pharmacologically induced stress, with interpretation and report; including performance of continuous electrocardiographic monitoring, with physician supervision	Special coverage instructions apply	—	2
Q9955	Injection, perflexane lipid microspheres, per ml	Carrier judgment	—	2
J3490	Unclassified drugs	Special coverage instructions apply	—	1
C9399	Unclassified drugs or biologicals	Special coverage instructions apply	—	1
G0283	Electrical stimulation (unattended), to one or more areas for indication(s) other than wound care, as part of a therapy plan of care	Carrier judgment	—	2
G0152	Services performed by a qualified occupational therapist in the home health or hospice setting, each 15 minutes	Carrier judgment	—	1
G0158	Services performed by a qualified occupational therapist assistant in the home health or hospice setting, each 15 minutes	Carrier judgment	—	1
G0160	Services performed by a qualified occupational therapist, in the home health setting, in the establishment or delivery of a safe and effective occupational therapy maintenance program, each 15 minutes	Carrier judgment	—	1
G2169	Services performed by an occupational therapist assistant in the home health setting in the delivery of a safe and effective occupational therapy maintenance program, each 15 minutes	Carrier judgment	—	1
G0281	Electrical stimulation, (unattended), to one or more areas, for chronic stage iii and stage iv pressure ulcers, arterial ulcers, diabetic ulcers, and venous stasis ulcers not demonstrating measurable signs of healing after 30 days of conventional care, as part of a therapy plan of care	Carrier judgment	—	1

1 more codes are listed. See every code with payment by region in Caduvo.

Medicare policy articles listing R22.2

A57306: Billing and Coding: Transthoracic Echocardiography (TTE) (CGS Administrators, LLC (MAC - Part A, MAC - Part B); 19 Level II codes). LCD with the same title: L33577, L34338
A56781: Billing and Coding: Transthoracic Echocardiography (TTE) (Wellpoint Federal (MAC - Part A, MAC - Part B); 17 Level II codes). LCD with the same title: L33577, L34338
A53057: Billing and Coding: Home Health Occupational Therapy (Palmetto GBA (HHH MAC); 5 Level II codes). LCD with the same title: L34560
A53064: Billing and Coding: Outpatient Occupational Therapy (Palmetto GBA (MAC - Part A); 3 Level II codes). LCD with the same title: L34427

A diagnosis listed as covered in a billing and coding article supports medical necessity for the article's codes; it does not guarantee payment. Coverage depends on the LCD's criteria, the contractor's jurisdiction and documentation in the medical record.

Other R22 diagnoses (Localized swelling, mass and lump of skin and subcutaneous tissue)

R22.0 — Localized swelling, mass and lump, head
R22.1 — Localized swelling, mass and lump, neck

Frequently asked questions

Does Medicare cover R22.2 (Localized swelling, mass and lump, trunk)?

Medicare covers items and services, not diagnoses. 4 Medicare billing and coding articles list R22.2 as a covered diagnosis for 26 HCPCS Level II codes: the diagnosis can support medical necessity for those codes, but payment still depends on the LCD's coverage criteria and the medical record.

Which HCPCS codes can be billed with ICD-10 R22.2?

The Level II codes from the policies most specific to this diagnosis are J2785 (Injection, regadenoson, 0.1 mg, 2 articles); J0461 (Injection, atropine sulfate, 0.01 mg, 2 articles); J0153 (Injection, adenosine, 1 mg (not to be used to report any…, 2 articles); Q9957 (Injection, perflutren lipid microspheres, per ml, 2 articles); J1250 (Injection, dobutamine hydrochloride, per 250 mg, 2 articles). Code choice depends on the item supplied; check each code's descriptor.

Which Medicare policy articles list R22.2?

A57306 (Billing and Coding: Transthoracic Echocardiography (TTE)); A56781 (Billing and Coding: Transthoracic Echocardiography (TTE)); A53057 (Billing and Coding: Home Health Occupational Therapy), and 1 more article.

What is ICD-10-CM code R22.2?

R22.2 is the ICD-10-CM code for localized swelling, mass and lump, trunk, in category R22 (Localized swelling, mass and lump of skin and subcutaneous tissue), chapter 18: Symptoms, signs and abnormal findings.

Next steps

Sources: CMS Medicare Coverage Database billing and coding articles (covered ICD-10 code lists and HCPCS links); ICD-10-CM FY2026; CMS HCPCS Level II release October 2026; CMS DMEPOS fee schedule 2026 (non-rural state fees). Not billing or legal advice.

Chapter 18: Symptoms, signs and abnormal findings · All diagnoses · HCPCS lookup